15563-65-2

Upstream product

• 67-56-1 methanol 
• 15563-56-1 N,N′?(4?chlorobenzylidene)bisbenzamide 
• 138768-30-6 N-<(benzotriazol-1-yl)(4-chlorophenyl)methyl>benzamide 
• 130256-25-6 N-[(4-Chloro-phenyl)-hydroxy-methyl]-benzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 55-21-0 benzamide 

Downstream Products

• 1332628-42-8 (4S,5R,6R,8aR)-acetic acid 5,6-bis-allyloxy-4-(4-chloro-phenyl)-2-phenyl-4a,6,7,8a-tetrahydro-4H, 5H-pyrano[3,2-e][1,3]oxazin-7-ylmethyl ester 
• 1431868-22-2 N-((4-chlorophenyl)(2,4,6-trimethoxyphenyl)methyl)benzamide 
• 15563-73-2 N-[(4-chlorophenyl)methylidene]benzamide 
• 1332628-27-9 (4S,6S,4aS,8aR)-acetic acid 7-acetoxymethyl-4-(4-chloro-phenyl)-2-phenyl-4a,6,7,8a-tetrahydro-4H, 5H-pyrano[3,2-e][1,3]oxazin-6-yl ester 

Relevant academic research and scientific papers

Synthesis of N-Acyl-N,O-acetals from Aldehydes, Amides and Alcohols

A general synthesis of N-acyl-N,O-acetals from aldehydes, amides and alcohols is reported. This new method consists of two single steps: (a) magnesium-mediated addition of an amide or carbamate to an aldehyde and (b) acid-catalyzed conversion of the N-acylhemiaminal to the N-acyl-N,O-acetal. This two-step protocol allows the multigram synthesis of various N-acyl-O-alkyl-N,O-acetals.

Heterobimetallic Ir-Sn catalysis: Aza-Friedel-Crafts reaction of N-sulfonyl aldimines

The heterobimetallic complex [Ir(COD)(SnCl3)Cl(μ-Cl)] 2 catalyzes the aza-Friedel-Crafts reaction of 1,3,5- trimethoxybenzene, as well as substituted indoles with N-sulfonyl aldimines leading to the formation of diarylamines and triarylmethanes in good yields. The symmetrical triarylmethanes were also obtained from diarylamines and suitable nucleophiles via simultaneous cleavage of sp3 C-N bond and elimination of 1,3,5-trimethoxybenzene.