155635-63-5

Upstream product

• 147381-62-2 6-(4-chlorophenyl)-3-cyano-4-trifluoromethyl-2(1H)-pyridone 
• 155635-60-2 2-[6-(4-Chloro-phenyl)-3-cyano-4-trifluoromethyl-pyridin-2-yloxy]-acetamide 

Downstream Products

• 168126-96-3 2-Amino-6-(4-chloro-phenyl)-4-trifluoromethyl-nicotinamide 
• 858358-80-2 ethyl 3-amino-6-(4-chlorophenyl)-1-phenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 
• 858358-88-0 3-amino-6-(4-chlorophenyl)-1-phenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
• 858358-72-2 2-phenylamino-6-(4-chlorophenyl)-4-trifluoromethylnicotinonitrile 

Relevant academic research and scientific papers

A simple one pot synthesis of novel tricyclic quinazolinones

Synthesis of a series of tricyclic quinazolinones have been accomplished starting from anthranilamide and 1,3-cyclic dione promoted by TsOH·H2O The protocol presented herein based on retro-Dieckmann type reaction, leading to incorporation of dione as an acyclic unit into the product. Simple reaction conditions, broad scope, excellent yields are the advantages of this protocol. Further, this methodology is extended to the synthesis of pyridopyrimidinones and benzimidazopyridines.

A novel synthetic route to 2-amino-3-cyano-4-trifluoromethyl-6-substituted pyridines

2-Amino-3-cyano-4-trifluoromethyl-6-substituted pyridines have been obtained from 3-cyano-4-trifluoromethyl-6-substituted-2(1H)pyridones via an interesting rearrangement of 2-O-acetamido-3-cyano-4-trifluoromethyl-6-substituted pyridine intermediates.