168126-96-3

Upstream product

• 155635-63-5 2-amino-3-cyano-4-trifluoromethyl-6-p-chlorophenylpyridine 
• 147381-62-2 6-(4-chlorophenyl)-3-cyano-4-trifluoromethyl-2(1H)-pyridone 

Relevant academic research and scientific papers

A simple one pot synthesis of novel tricyclic quinazolinones

Synthesis of a series of tricyclic quinazolinones have been accomplished starting from anthranilamide and 1,3-cyclic dione promoted by TsOH·H2O The protocol presented herein based on retro-Dieckmann type reaction, leading to incorporation of dione as an acyclic unit into the product. Simple reaction conditions, broad scope, excellent yields are the advantages of this protocol. Further, this methodology is extended to the synthesis of pyridopyrimidinones and benzimidazopyridines.

A mild and efficient method for the dehydrogenation of dihydropyridopyrimidinones and related compounds by using active MnO2

Various fluorinated dihydropyridopyrimidin-4-ones (3) are conveniently oxidised to respective pyridopyrimidin-4-(3H)-ones (4) in quantitative yields by using active MnO2.This method has been generalised by applying to other related heterocyclic compounds.