155645-51-5

Basic information

• Product Name: Cyclo[(2R)-2-methyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-O-methyl-D-tyrosyl]
• Synonyms: b-Alanine, N-[N-[5-[(2-hydroxy-4-methyl-1-oxopentyl)oxy]-6-methyl-1-oxo-8-phenyl-2,7-octadienyl]-O-methyl-D-tyrosyl]-2-methyl-,x-lactone,[5S-[1(S*),2E,5R*(R*),6S*,7E]]-; Cryptophycin 4; Cryptophycin D
• CAS NO: 155645-51-5
• Molecular Formula: C35H44 N2 O7
• Molecular Weight: 604.744
• Mol File: 155645-51-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Cyclo[(2R)-2-methyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-O-methyl-D-tyrosyl](CAS DataBase Reference)
• NIST Chemistry Reference: Cyclo[(2R)-2-methyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-O-methyl-D-tyrosyl](155645-51-5)
• EPA Substance Registry System: Cyclo[(2R)-2-methyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-O-methyl-D-tyrosyl](155645-51-5)

Safety Data

• Hazardous Substances Data: 155645-51-5(Hazardous Substances Data)

Upstream product

• 162465-18-1 (S)-2-((R)-3-Amino-2-methyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 869195-59-5 C₃₅H₄₆N₂O₈ 
• 4440-01-1 lithium phenylacetylide 
• 178977-50-9 (4S,5S)-4-Hydroxy-5-phenylethynyl-dihydro-furan-2-one 
• 1054658-49-9 2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester 
• 178977-40-7 (R)-3-[(R)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-2-methyl-propionic acid 
• 178977-62-3 (2E,7E)-(5S,6R)-6-Methyl-8-phenyl-5-(tetrahydro-pyran-2-yloxy)-octa-2,7-dienoic acid tert-butyl ester 
• 178977-60-1 2,2-Dimethyl-propionic acid (E)-(3S,4R)-4-methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester 
• 178977-55-4 (3S,4S)-2,2-dimethylpropionic acid 4-acetoxy-3-hydroxy-6-phenylhex-5(E)-enyl ester 
• 178977-54-3 (3S,4S)-3-(tetrahydropyran-2-yloxy)-6-phenylhex-5(E)-ene-1,4-diol 
• 178977-61-2 (E)-(3S,4R)-4-Methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-en-1-ol 
• 178977-56-5 (3S,4S)-2,2-dimethylpropionic acid 3-hydroxy-4-methyl-6-phenylhex-5(E)-enyl ester 
• 181656-42-8 (E)-(3S,4R)-3-Hydroxy-4-methyl-6-phenyl-hex-5-enoic acid 
• 68856-96-2 N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine 

Relevant articles and documents

Frontiers and opportunities in chemoenzymatic synthesis

Natural product biosynthetic pathways have evolved enzymes with myriad activities that represent an expansive array of chemical transformations for constructing secondary metabolites. Recently, harnessing the biosynthetic potential of these enzymes through chemoenzymatic synthesis has provided a powerful tool that often rivals the most sophisticated methodologies in modern synthetic chemistry and provides new opportunities for accessing chemical diversity. Herein, we describe our research efforts with enzymes from a broad collection of biosynthetic systems, highlighting recent progress in this exciting field.

A synthesis of cryptophycin 4 using a planar chiral molybdenum cationic complex

A synthesis of cytotoxic agent Cryptophycin 4 features a new approach to (5S,6R)-5-hydroxy-6-methyl-8-phenyl-(2E,7E)-dienoic acid in which the anti stereochemistry between two stereogenic centres is secured by addition of a 1,3-dioxan-4-ylcopper(I) reagen

Total Synthesis of Cryptophycins-1, -3, -4, -24 (Arenastatin A), and -29, Cytotoxic Depsipeptides from Cyanobacteria of the Nostocaceae

A convergent synthesis of cryptophycins has been developed in which (5S,6R)-5-hydroxy-6-methyl-8-phenylocta-2(E),7(E)-dienoic acid (A) is coupled with an amino acid segment (B). Two stereo-selective routes to A are described, the first employing allylatio