178977-61-2

Basic information

• Product Name: (E)-(3S,4R)-4-Methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-en-1-ol
• Synonyms: (E)-(3S,4R)-4-Methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-en-1-ol
• CAS NO: 178977-61-2
• Molecular Weight: 290.403
• Mol File: 178977-61-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-(3S,4R)-4-Methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(3S,4R)-4-Methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-en-1-ol(178977-61-2)
• EPA Substance Registry System: (E)-(3S,4R)-4-Methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-en-1-ol(178977-61-2)

Safety Data

• Hazardous Substances Data: 178977-61-2(Hazardous Substances Data)

Upstream product

• 4440-01-1 lithium phenylacetylide 
• 178977-50-9 (4S,5S)-4-Hydroxy-5-phenylethynyl-dihydro-furan-2-one 
• 1054658-49-9 2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester 
• 178977-55-4 (3S,4S)-2,2-dimethylpropionic acid 4-acetoxy-3-hydroxy-6-phenylhex-5(E)-enyl ester 
• 178977-54-3 (3S,4S)-3-(tetrahydropyran-2-yloxy)-6-phenylhex-5(E)-ene-1,4-diol 
• 178977-56-5 (3S,4S)-2,2-dimethylpropionic acid 3-hydroxy-4-methyl-6-phenylhex-5(E)-enyl ester 
• 110-87-2 3,4-dihydro-2H-pyran 
• 178977-60-1 2,2-Dimethyl-propionic acid (E)-(3S,4R)-4-methyl-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester 
• 181656-42-8 (E)-(3S,4R)-3-Hydroxy-4-methyl-6-phenyl-hex-5-enoic acid 

Downstream Products

• 178977-57-6 tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate 
• 245125-92-2 tert-butyl (5S,6R)-5-[(2S)-2-[(2R)-3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-propionylamino]-2-methylpropionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),7(E)-dienoate 
• 182486-25-5 tert-butyl (5S,6R)-5-[(2S)-2-[(2R)-3-[(2R)-2-tert-butoxycarbonylamino-3-(3-chloro-4-methoxyphenyl)propionylamino]-2-methylpropionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),7(E)-dienoate 
• 124689-64-1 cryptophycin C 
• 155645-51-5 Cryptophycin 4 
• 178977-62-3 (2E,7E)-(5S,6R)-6-Methyl-8-phenyl-5-(tetrahydro-pyran-2-yloxy)-octa-2,7-dienoic acid tert-butyl ester 

Relevant articles and documents

Synthesis and in vitro cytotoxicity of cryptophycins and related analogs

Several members of the Cryptophycin family were synthesised using a straightforward convergent approach. The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines.