155672-34-7Relevant academic research and scientific papers
Compound with AMPK agonistic activity and preparation and application of prodrug thereof
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Paragraph 0145; 0153-0154; 0423; 0427-0428, (2021/10/27)
The invention relates to a compound with AMPK agonistic activity and a prodrug thereof, and as well as a preparation method and medical application of a prodrug thereof. The compound has the structure shown in the formula (I), and the prodrug of the compound has the structure shown in the formula (II), wherein each group and the substituent are as defined in the specification. The invention discloses a preparation method of the compound and application of the compound in prevention and treatment AMPK related diseases, and the AMPK related diseases include, but are not limited to, energy metabolism abnormality related diseases. Neurodegenerative diseases and inflammation-related diseases and the like.
Synthesis of Isomeric Methyl ε-Hydroxycarboxylates
Arth, Christoph,Clemens, Martina,Meise, Werner
, p. 259 - 264 (2007/10/02)
The synthesis of the three isomeric methyl ε-hydroxycarboxylates 3, 6 and 10a in good overall yields is described. - Key Words: Methyl ε-hydroxycarboxylates / Carboxylic acids, ε-hydroxy- / Phenylalkanoic acids, o-(hydroxyalkyl)-
