136863-22-4Relevant academic research and scientific papers
The aldol type reaction catalyzed by arylmalonate decarboxylase - A decarboxylase can catalyze an entirely different reaction, aldol reaction
Terao, Yosuke,Miyamoto, Kenji,Ohta, Hiromichi
, p. 420 - 421 (2007/10/03)
The catalytic promiscuity of AMDase was demonstrated using a well-designed substrate based on the consideration of the reaction mechanism. As the reaction catalyzed by AMDase is supposed to proceed via an enolate intermediate, we expected that the enzyme
Lithium 2-(2-lithiomethylphenyl)ethanolate from isochroman: Easy preparation of substituted benzoxepines and functionalised arenes
Almena, Juan,Foubelo, Francisco,Yus, Miguel
, p. 3365 - 3374 (2007/10/02)
The reaction of isochroman (1) with an excess of lithium powder and a catalytic amount of DTBB (2.5 mol %) in THF at 20°C yields the title intermediate, which by reaction with different electrophiles (H2O, D2O, CO2 and carbonyl compounds) at temperatures ranging between -78 and 20°C yields, after hydrolysis, the corresponding products 3. Diols 3h-m, derived from benzaldehyde or ketones, give upon treatment with 85% phosphoric acid the corresponding benzoxepines 5h-m. In the other cases, Friedel-Crafts products resulting from a rearrangement of the first carbenium ion formed, are obtained.
Synthesis of Isomeric Methyl ε-Hydroxycarboxylates
Arth, Christoph,Clemens, Martina,Meise, Werner
, p. 259 - 264 (2007/10/02)
The synthesis of the three isomeric methyl ε-hydroxycarboxylates 3, 6 and 10a in good overall yields is described. - Key Words: Methyl ε-hydroxycarboxylates / Carboxylic acids, ε-hydroxy- / Phenylalkanoic acids, o-(hydroxyalkyl)-
Synthesis of Aromatic Annulated ε-Lactones
Meise, Werner,Arth, Christoph
, p. 163 - 166 (2007/10/02)
The synthesis of three isomeric benzoxepinones 2, 7 and 8 by oxidation of the ω-diols 1 and 6 with silver carbonate on Celite is reported. Key Words: ε-Lactones / Oxidation of ω-diols with silver carbonate on Celite
