155689-45-5Relevant academic research and scientific papers
SPIROCYCLIC DIPEPTIDES OF 1-AMINO-1-CYCLOHEXANECARBOXYLIC ACID
Vinsova, Jarmila,Kosar, Karel,Kasafirek, Evzen
, p. 195 - 202 (1994)
Spirocyclic cyclodipeptides with 1-amino-1-cyclohexanecarboxylic acid of the general formula cyclo(-Ach-A-), where A is Gly, L-Ala, D-Ala, L-Val, D-Val, L-Leu, D-Leu, D-Pgl, L-Phe or D-Phe, have been prepared by cyclization of the corresponding linear dipeptide methyl esters.The peptides cyclo(-L- or D-Ala-Ach-), cyclo(-L-Val-Ach-) and cyclo(-D-Leu-Ach-) show higher activity in the Chick Embryotoxicity Screening Test when compared with derivatives containing 1-amino-1-cyclopentanecarboxylic acid or 1-amino-1-cyclobutanecarboxylic acid.
