155719-53-2

Upstream product

• 108-90-7 chlorobenzene 
• 79686-90-1 N-(methoxycarbonyl)aspartic anhydride 

Downstream Products

• 220283-81-8 methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate 
• 166764-44-9 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoic acid trimethylsilyl ester 

Relevant academic research and scientific papers

New silane reduction of aromatic ketones mediated by titanium tetrachloride : A synthesis of γ- and δ-aryl substituted amino acids

Several N-protected 4-aryl-2-aminobutanoic acids (γ-aryl substituted amino acids ; 7a-f) and N-protected 5-aryl-2-aminopentanoic acids (δ-aryl substituted amino acids ; 8a,b and d) were prepared in good yields by reduction of the corresponding aromatic or heteroaromatic ketones (3 and 4) with triethylsilane (Et3SiH) or dimethylphenylsilane (PhMe2SiH) in the presence of titanium tetrachloride (TiCl4), respectively. The reduction proceeded without racemization and was successfully applied to the synthesis of optically active γ-and δ-aryl substituted amino acids (14a and 15a).

Pyridazinone derivatives and processes for preparing the same

Disclosed are a pyridazinone compound represented by the formula: STR1 wherein (1) R1 is a substituted or unsubstituted C1-10 alkyl, a C3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R1 and R3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: STR2 where n is 1 or 2; and D is hydrogen or a halogen; or (2) R1 is a substituted or unsubstituted C1-10 alkyl, a substituted or unsubstituted phenyl, a C3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R1 and R3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: STR3 and R2 is hydrogen, a substituted or unsubstituted lower alkyl, an aryl or a lower alkenyl; and --A--B-- is an ethylene or vinylene each of which may be substituted by 1 or 2 groups selected from the group consisting of a lower alkyl and phenyl group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same.