155726-05-9

Basic information

• Product Name: (R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE
• Synonyms: (R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE;(R)-1-METHYL-2-(PIPERIDINOMETHYL)PYRROLIDINE;(R)-1-((1-methylpyrrolidin-2-yl)methyl)piperidine;1-{[(2R)-1-Methylpyrrolidin-2-yl]Methyl}piperidine;1-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]piperidine;-1-((1-Methylpyrrolidin-2-yl);Piperidine, 1-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-
• CAS NO: 155726-05-9
• Molecular Formula: C11H22N2
• Molecular Weight: 182.31
• Mol File: 155726-05-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 236.1±8.0 °C(Predicted)
• Appearance: /
• Density: 0.954±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.39±0.40(Predicted)
• CAS DataBase Reference: (R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE(155726-05-9)
• EPA Substance Registry System: (R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE(155726-05-9)

Safety Data

• Hazardous Substances Data: 155726-05-9(Hazardous Substances Data)

Usage

General Description

"(R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE" is a chemical compound that belongs to the class of piperidine derivatives. It is a chiral molecule, existing in two enantiomeric forms, with the (R)-(+)-enantiomer being the active form. (R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE is used in the synthesis of various pharmaceuticals and organic compounds. It has been studied for its potential applications in the field of medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases and conditions. The (R)-(+)-1-[(1-METHYL-2-PYRROLIDINYL)METHYL]PIPERIDINE may also be used as a building block in the synthesis of other complex molecules with biological activity. Overall, this compound has significant importance in the field of organic chemistry and drug development.

Upstream product

• 147-85-3 L-proline 
• 118916-60-2 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one 
• 110-89-4 piperidine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Relevant articles and documents

Synthesis of chiral diamines using novel 2-trichloromethyloxazolidin-4-one precursors derived from 5-oxo-proline and proline

Efficient syntheses of chiral vicinal diamines derived from (S)-oxo-proline and (S)-proline are described. The novel diastereomerically pure precursor (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo-[3.3.0]-octan-4,8-dione 3 and its enantiomer are readily available by reaction of the inexpensive enantiomers of 5-oxo-proline with chloral. Compound 3 reacts with primary and secondary amines to afford the 5-oxo-prolylamides 4 in quantitative yield. In contrast, the (S)-proline-derived precursor (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one 6 gave (S)-N-formylprolylamides 9 and/or (S)-prolylamides 8 depending on the reaction conditions. Upon reduction with LiAlH4, amides 4 and 9 afforded the proline-derived (S)-2-(alkylaminomethyl)pyrrolidines 1 and (S)-N-methyl-2-(alkylaminomethyl)-pyrrolidines 5 in 70-90% yields.

HIGHLY ENANTIOSELECTIVE ALDOL-TYPE REACTION OF 3-ACETYLTHIAZOLIDINE-2-THIONE WITH ACHIRAL ALDEHYDES

A highly enantioselective aldol-type reaction forming various β-hydroxy carbonyl compounds from 3-acetylthiazolidine-2-thione and achiral aldehydes is achieved via divalent tin enolate employing chiral diamine derived from (S)-proline as a ligand.