155773-72-1Relevant articles and documents
Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers
Yiyun, Cheng,Tongwen, Xu
, p. 1188 - 1192 (2005)
The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimers at 37°C. The effect of concentration and generation of the PAMAM dendrimers has been investigated. Results showed that the solubility of NSAIDs in the PAMAM dendrimer solutions was approximately proportional to dendrimer concentration; the solubility of NSAIDs in higher generation PAMAM solutions was in fact higher that those in lower ones; the order of increased solubility of NSAIDs in PAMAM dendrimers at a constant dendrimer concentration and generation was Naproxen > Ketoprofen > Ibuprofen > Diflunisal. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs.
The synthesis of water soluble dendrimers, and their application as possible drug delivery systems
Twyman, Lance J.,Beezer, Anthony E.,Esfand,Hardy, Martin J.,Mitchell, John C.
, p. 1743 - 1746 (1999)
The synthesis of two water soluble dendrimers is described. The formation of water soluble inclusion complexes with a variety of small, hydrophobic guest molecules is also described. Moreover, when these guest molecules are drug moieties, then the resulting drug/dendrimer complexes can be considered ideal candidates for use as novel drug delivery systems.
Efficient oral insulin delivery by dendronized chitosan: In vitro and in vivo studies
Mukhopadhyay, Piyasi,Sarkar, Kishor,Bhattacharya, Sourav,Mishra, Roshnara,Kundu
, p. 43890 - 43902 (2014)
The development of efficient and bio-safe polymeric carriers for oral insulin delivery is a major thrust in biomedical research. In this paper, dendronized chitosan (DCTS) is prepared using a Michael-type addition reaction by grafting polyamidoamine (PAMAM) onto chitosan to improve its water solubility, pH sensitivity, and insulin encapsulation efficiency for enhanced bioavailability of the oral insulin. The self-assembled dendronized chitosan nanoparticles are prepared using a mild coacervation method, in which almost sub-spherically shaped nanoparticles of 85-150 nm size are produced, with an insulin encapsulation of approx. 95%. In vitro release study confirms a pH-sensitive and self-sustained release of insulin, where the oral administration of these nanoparticles exhibits a pronounced hypoglycemic effect in diabetic mice, producing a relative bioavailability of ～9.19%. As no systemic toxicity is observed with its peroral delivery, these DCTS nanoparticles can effectively serve as a promising device in the efficient administration of oral insulin. This journal is
Modified PAMAM dendrimers as a matrix for the photostabilization of curcumin
Dodangeh, Mohammad,Grabchev, Ivo,Gharanjig, Kamaladin,Staneva, Desislava,Tang, Ren-Cheng,Sheridan, Matthew
supporting information, p. 17112 - 17121 (2020/10/27)
Six recently synthesised poly(amidoamine) (PAMAM) dendrimers from zero, first and second generations modified with 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (curcumin) and 2,4-dihydroxybenzophenone (CU-1, CU-2, CU-3, CU-4, CU-5 and CU-6) have been investigated in water/dioxane (4 : 1) (v/v) solution by absorption and fluorescence spectroscopy in order to determine their photostability. It has been found that the photostability of curcumin is enhanced upon its incorporation into the dendrimer molecule, and a new additional stabilization is achieved by bonding of 2,4-dihydroxybenzophenone as a UV absorber to the dendrimer molecule. It has also been established that the generation of dendrimers impacts upon this parameter as the photostabilizing effect enhances at a higher dendrimer generation. The photostability of the dendrimers has also been investigated after their deposition onto a polyethylene terephthalate (PET) fabric. This journal is
Antimicrobial efficacy of synthesized quaternary ammonium polyamidoamine dendrimers and dendritic polymer network
Zainul Abid,Jackeray, Richa,Jain, Swati,Chattopadhyay, Sruti,Asif,Singh, Harpal
, p. 998 - 1007 (2016/03/08)
Water treatment to mitigate microbial contaminants is a major challenge across globe paving the way to develop novel antimicrobial compounds. We aim at architecting antibacterial moiety eventually catering to vast water treatment industry. In this research study, quaternary ammonium functionalized polyamidoamine (PAMAM) dendrimer and PAMAM-ethyleneglycol dimethacrylate (EGDMA) dendritic polymer network were synthesized. These materials were characterized by various analytical techniques like ATR-FTIR, 1HNMR, DSC etc. Water soluble generation (G) 1.0 PAMAM dendrimer and water insoluble PAMAM G1.0 EGDMA dendritic polymer network were quaternized by reacting with dilute hydrochloric acid (HCl) and octyl iodide (OI) respectively. Both quaternary ammonium dendrimer products were found to exhibit potent bactericidal activity against a group of common Gram-negative and Gram-positive bacteria. 10 mg/L concentration of liquid PAMAM G1.0 QHCl was efficient to kill 100% bacteria rapidly within an incubation time of just 2 minutes. In addition, quaternary ammonium dendritic polymer network PAMAM G1.0-EGDMA Q OI demonstrated good contact killing antimicrobial property without releasing any active molecule into the surrounding medium and disinfected contaminated water within 5 minutes. Both quaternary ammonium dendrimer and dendritic polymer network showed negligible cytotoxicity in MTT assay indicating their potential as a viable antimicrobial agent.
