155779-30-9Relevant academic research and scientific papers
Preparation of chiral indanones and dihydrocoumarins; Application to synthesis of (+)-3-(2,6-dimethoxyphenyl) pentanoic acid
Stephan,Rocher,Aubouet,Pourcelot,Cresson
, p. 41 - 44 (2007/10/02)
Chiral β-aryl carboxylic acids, prepared by Michael addition of organocuprates to chiral unsaturated imides, are transformed into chiral 3- alkyl-4-benzoyloxyindan-1-ones via two intramolecular acylations, with intermediate formation of chiral 3-alkylindanones and corresponding dihydrocoumarins. The 3-(S)-ethyl-4-benzoyloxyindanone is transformed into(+)-3-(S)-(2,6-dimethoxyphenyl)pentanoic acid.
