15581-15-4Relevant academic research and scientific papers
A three-component approach to isoxazolines and isoxazoles under metal-free conditions
Wang, Dahan,Zhang, Feng,Xiao, Fuhong,Deng, Guo-Jun
, p. 9163 - 9168 (2019)
A 1,3-dipolar cycloaddition of 2-methylquinoline, tert-butyl nitrite (TBN) and alkynes or alkenes for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs has been developed. In this protocol, TBN serves as a convenient N-O source to convert 2-methylquinoline into intermediate nitrile oxides in situ.
