7063-98-1

Basic information

• Product Name: 11-(5-{[5-cyano-2-(2,6-dimethylmorpholin-4-yl)-1-ethyl-4-methyl-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)undecanoic acid
• CAS NO: 7063-98-1
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 602.8083
• Mol File: 7063-98-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 628.7°C at 760 mmHg
• Flash Point: 334°C
• Density: 1.28g/cm³
• Vapor Pressure: 2.02E-17mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 11-(5-{[5-cyano-2-(2,6-dimethylmorpholin-4-yl)-1-ethyl-4-methyl-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)undecanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(5-{[5-cyano-2-(2,6-dimethylmorpholin-4-yl)-1-ethyl-4-methyl-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)undecanoic acid(7063-98-1)
• EPA Substance Registry System: 11-(5-{[5-cyano-2-(2,6-dimethylmorpholin-4-yl)-1-ethyl-4-methyl-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)undecanoic acid(7063-98-1)

Safety Data

• Hazardous Substances Data: 7063-98-1(Hazardous Substances Data)

Upstream product

• 75096-75-2 2-methyl-5-phenyl-pyrrol-3-one oxime 
• 60-29-7 diethyl ether 
• 536-74-3 phenylacetylene 
• 67-56-1 methanol 
• 57-71-6 2,3-Butanedione monoxime 
• 877-94-1 phenyl-5 pentene-4 one-2 
• 10230-68-9 1-nitro-2-propanone 
• 67-64-1 acetone 
• 860544-98-5 1-phenyl-pentane-1,3,4-trione trioxime 
• 1004-22-4 (phenylethynyl)sodium 
• 7697-37-2 nitric acid 
• 583-05-1 1-phenylpentane-1,4-dione 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 

Downstream Products

• 34671-20-0 1-(5-phenyl-isoxazol-3-yl)-ethanone (4-nitro-phenyl)-hydrazone 
• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 
• 15581-15-4 5-phenyl-3-(quinoxalin-2-yl)isoxazole 
• 13788-08-4 isonicotinic acid [2-oxo-2-(5-phenyl-isoxazol-3-yl)-ethylidene]-hydrazide 
• 13788-07-3 4-[2-oxo-2-(5-phenyl-isoxazol-3-yl)-ethylideneamino]-benzoic acid 
• 104777-29-9 N-[4-(5-Phenyl-isoxazol-3-yl)-thiazol-2-yl]-oxalamic acid 
• 104777-00-6 N-[4-(5-Phenyl-isoxazol-3-yl)-thiazol-2-yl]-oxalamic acid 2-ethoxy-ethyl ester 
• 104776-82-1 4-(5-Phenyl-isoxazol-3-yl)-thiazol-2-ylamine 
• 49637-06-1 2-bromo-1-(5-phenyl-isoxazol-3-yl)-ethanol 
• 115697-65-9 2-Isopropylamino-1-(5-phenyl-isoxazol-3-yl)-ethanol 
• 27409-56-9 3-(1-Hydroxy-1-methylethyl)-5-phenylisoxazole 
• 14731-15-8 2-bromo-1-(5-phenyl-isoxazol-3-yl)-ethanone 
• 13788-04-0 oxo-(5-phenyl-isoxazol-3-yl)-acetaldehyde hydrate 

Relevant articles and documents

Transition-Metal-Free Multicomponent Approach to Stereoenriched Cyclopentyl-isoxazoles through C?C Bond Cleavage

An efficient multicomponent reaction for the synthesis of stereoenriched cyclopentyl-isoxazoles from camphor-derived α-oximes, alkynes, and MeOH is reported. Our method involved a series of cascade transformations, including the in situ generation of an IIII catalyst, which catalyzed the addition of MeOH to a sterically hindered ketone. Oxidation of the oxime, and rearrangement of the α-hydroxyiminium ion generated a nitrile oxide in situ, which, upon [3+2] cycloaddition reaction with an alkyne, delivered the regioselective product. This reaction was very selective for the syn-oxime. This multicomponent approach was also extended to the synthesis of a new glycoconjugate, camphoric ester-isoxazole C-galactoside.

Synthetic Diversity from a Versatile and Radical Nitrating Reagent

We leverage the slow liberation of nitrogen dioxide from a newly discovered, inexpensive succinimide-derived reagent to allow for the C?H diversification of alkenes and alkynes. Beyond furnishing a library of aryl β-nitroalkenes, this reagent provides unparalleled access to β-nitrohydrins and β-nitroethers. Detailed mechanistic studies strongly suggest that a mesolytic N?N bond fragmentation liberates a nitryl radical. Using in situ photo-sensitized, electron paramagnetic resonance spectroscopy, we observed direct evidence of a nitryl radical in solution by nitrone spin-trapping. To further exhibit versatility of N-nitrosuccinimide under photoredox conditions, the late-stage diversification of an extensive number of C?H partners to prepare isoxazolines and isoxazoles is presented. This approach allows for the formation of an in situ nitrile oxide from a ketone partner, the presence of which is detected by the formation of the corresponding furoxan when conducted in the absence of a dipolarophile. This 1,3-dipolar cycloaddition with nitrile oxides and alkenes or alkynes proceeds in a single-operational step using a mild, regioselective, and general protocol with broad chemoselectivity.

The branch part and delivery system, the catheter assembly

A catheter assembly including a side branch locator that is moveable between a retracted position within a main vessel of a vessel bifurcation, and an extended position wherein a distal end of the side branch locator extends into a branch vessel of the vessel bifurcation. The side branch locator includes a first end fixed relative to a portion of the catheter assembly that remains in the main vessel. A second end of the side branch locator is moveable between the retracted and extended positions. The catheter assembly can include a moveable sheath that holds the side branch locator in the retracted position. The catheter assembly can further include a stent having a lateral branch opening through which the side branch locator extends.