15582-94-2

Upstream product

• 770-85-4 2-methyl-2-phenylbutan-3-one 
• 563-80-4 3-methyl-butan-2-one 
• 100-25-4 para-dinitrobenzene 
• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 74-88-4 methyl iodide 
• 2648-71-7 3-bromo-3-methyl-2-butanone 
• 40919-12-8 2-methyl-2-(4-nitro-phenyl)-propionyl chloride 
• 506-82-1 dimethylcadmium 

Downstream Products

• 561297-77-6 1-dimethylamino-4-methyl-4-(4-nitro-phenyl)-pent-1-en-3-one 
• 1309381-02-9 C₁₈H₂₀N₂O₆S 
• 1309381-01-8 C₂₁H₂₀N₂O₅S 
• 1309380-82-2 3-methyl-3-(p-nitrophenyl)-2-butanone oxime 
• 857293-82-4 N-(2-(p-nitrophenyl)-2-propyl)acetamide 
• 22357-57-9 2-(4-nitrophenyl)propan-2-ol 

Relevant academic research and scientific papers

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

NUCLEOPHILIC SUBSTITUTION p-DINITROBENZENE WITH SOME CARBANIONS. FORMATION OF p-SUBSTITUTED NITROBENZENES

Treatment of p-dinitrobenzene with active methylene compounds of rather weak acidity in the presence of t-BuOK in liq NH3 at -70'C leads to nucleophilic substitution of a nitro group, giving p-substituted nitrobenzenes in generally good yields.