15584-07-3Relevant academic research and scientific papers
Synthesis, Characterization, and Antioxidant Activities of Genistein, Biochanin A, and Their Analogues
Hamza Sherif, Salah,Gebreyohannes, BerihuTekluu
, (2018/04/30)
A series of naturally occurring genistein (3) and biochanin A (4) compounds and their analogues were synthesized from phloroglucinol. The structures of all the synthesized compounds were established by the combined use of 1HNMR, 13CNMR, IR spectral data, and mass spectrometry; their antioxidant activities were investigated. Most of the synthesized compounds show moderate-to-high activity; only two compounds exhibit no significant activity.
In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases
Mascayano, Carolina,Espinosa, Victoria,Sepulveda-Boza, Silvia,Hoobler, Eric K.,Perry, Steve
, p. 317 - 325 (2013/09/12)
In this study, we have investigated 16 isoflavone and isoflavan derivatives as potential inhibitors of human lipoxygenase (platelet 12-lipoxygenase, reticulocyte 15-lipoxygenase-1, and epithelial 15-lipoxygenase-2). The flavonoid baicalein, a known lipoxygenase inhibitor, was used as positive control. Four compounds, 6,7-dihydroxy-3′-chloroisoflavone (1c), 7-hydroxy-8-methyl-4′-chloroisoflavan (5a), 7,8-dihydroxy-4′-methylisoflavan (5b), and 7,8-dihydroxy-3′-methylisoflavan (5c), were effective inhibitors of 12-lipoxygenases and 15-lipoxygenase-1 with IC50's i values in the range of 0.3-3 μm.
Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo
Stachulski, Andrew V.,Berry, Neil G.,Low, Lilian A.C.,Moores, Shelley L.,Row, Eleanor,Warhurst, David C.,Adagu, Ipemida S.,Rossignol, Jean-Fran?ois
, p. 1450 - 1454 (2007/10/03)
We report the preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein. These analogues retain the 5,7-dihydroxyisoflavone core of genistein: direct genistein analogues (2-H isoflavones), 2-car
Ground mixture
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, (2008/06/13)
A ground mixture of a poorly soluble crystalline drug and an adsorbent is remarkably improved in the rates of dissolution and adsorption of the drug.
