1558987-36-2Relevant academic research and scientific papers
Facile synthesis of Hantzsch 1,4-dihydropyridines with unsymmetrical 2,6-and 3,5-substituents
Wang, Zhen,Liu, Qingjian,Zhang, Wenwen,Chen, Qing
, p. 748 - 750 (2013)
A facile synthesis of Hantzsch 1,4-dihydropyridines with unsymmetrical 2,6- and 3,5-substituents in a one-pot two-step tandem reaction under solvent-free conditions, promoted by microwave irradiation, has been developed. No catalysts are used and the work-up is easy. This approach provides a convenient, efficient and practical synthesis of 1,4-dihydropyridines having non-identical substituents at the 2,6- and 3,5- positions, which are not easily accessed by the classical Hantzsch synthesis.
