1559008-50-2Relevant academic research and scientific papers
First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors
Oueis, Emilia,Nachon, Florian,Sabot, Cyrille,Renard, Pierre-Yves
supporting information, p. 2043 - 2045 (2014/03/21)
The irreversible Michael addition of thiols to acrylamides is reported as a new tool for the kinetic target-guided synthesis. In an unprecedented enzymatic hydrolysis/thio-Michael addition procedure, potent and selective acetylcholinesterase inhibitors are assembled by the enzyme using both its esterasic and templating ability.
