155906-13-1

Basic information

• Product Name: 2,5-Difluoro-4-iodoaniline
• Synonyms: 2,5-Difluoro-4-iodoaniline;2,5-Difluoro-4-iodo-phenylamine
• CAS NO: 155906-13-1
• Molecular Formula: C₆H₄F₂IN
• Molecular Weight: 255.0039364
• Mol File: 155906-13-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2,5-Difluoro-4-iodoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Difluoro-4-iodoaniline(155906-13-1)
• EPA Substance Registry System: 2,5-Difluoro-4-iodoaniline(155906-13-1)

Safety Data

• Hazardous Substances Data: 155906-13-1(Hazardous Substances Data)

Usage

General Description

2,5-Difluoro-4-iodoaniline is a chemical compound with the molecular formula C6H4F2IN. It is a halogenated aniline derivative, featuring two fluorine atoms at the 2 and 5 positions and an iodine atom at the 4 position on the benzene ring. 2,5-Difluoro-4-iodoaniline is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the manufacture of dyes and pigments. The presence of fluorine and iodine in the molecule provides unique reactivity and opportunities for further functionalization, making 2,5-Difluoro-4-iodoaniline a valuable compound in the field of organic chemistry.

Upstream product

• 112279-60-4 4-bromo-2,5-difluoroaniline 
• 367-30-6 2,5-difluoroaniline 

Downstream Products

• 1415730-99-2 8-(3-phenyl[1,2,4]oxadiazol-5-yl)-1-oxa-2,8-diazaspiro[4.5]-dec-2-ene-3-carboxylic acid (2,5-difluoro-4-methylsulfanylphenyl)amide 
• 1415731-00-8 C₂₃H₂₁F₂N₅O₄S 
• 1415731-01-9 2,5-difluoro-4-(methylsulfanyl)phenylamine 
• 910487-20-6 N-(2,5-difluoro-4-iodophenyl)methanesulfonamide 
• 307306-10-1 2,5-difluoro-4-(β-D-glycero-pentofuran-3-ulos-1-yl)aniline 
• 320592-23-2 4-[5-(((p-chlorobenzoyl)oxy)methyl)-4-(benzyloxy)-2,5-dihydro-β-L-furan-2-yl]-2,5-difluoroaniline 

Relevant articles and documents

P -Toluenesulfonic Acid Induced Conversion of Fluorinated Trimethylsilylethynylanilines into Aminoacetophenones: Versatile Precursors for the Synthesis of Benzoazaheterocycles

A simple and efficient approach to the synthesis of fluorinated amino-substituted acetophenones in good to excellent yields is reported. The heart of the proposed method consists of conversion of a Me 3 Si-C≡C- moiety into a MeC(=O)- group in the presence of p -tolu ene sulfonic acid (p -TSA) passing a stage of ethynylaniline formation. The reaction is metal-free, proceeds under mild conditions, and uses readily available starting compounds (trimethylsilylarylacetylene derivatives). The reaction provides access to amino-substituted acetophenones, which may serve as precursors for the synthesis of polyfluorinated azaheterocycles, having potential anticarcinogenic activity.

Identification of new potent GPR119 agonists by combining virtual screening and combinatorial chemistry

Virtual screening in a huge collection of virtual combinatorial libraries has led to the identification of two new structural classes of GPR119 agonists with submicromolar in vitro potencies. Herein, we describe the virtual screening process involving feature trees fragment space searches followed by a 3D postprocessing step. The in silico findings were then filtered and prioritized, and finally, combinatorial libraries of target molecules were synthesized. Furthermore the so-called activity-anchor principle is introduced as an element to increase the chance to generate true hits. An activity anchor is a structural element expected to provide key contributions to a certain biological activity. Application of this technique has led to the discovery of two new GPR119-agonist hit series, one of which was further optimized to progress as a novel lead class.

Tolane derivatives, liquid crystal compositions containing the derivatives and liquid crystal display devices using the compositions

A tolane derivative, a liquid crystal composition containing the derivative, and a liquid crystal display device including the composition, in which the tolane derivative is represented by the following general formula: STR1 wherein R represents a straigh