1559077-94-9

Basic information

• Product Name: (E)-1-bromo-3-(3,3,3-trifluoroprop-1-en-1-yl)benzene
• Synonyms: (E)-1-bromo-3-(3,3,3-trifluoroprop-1-en-1-yl)benzene
• CAS NO: 1559077-94-9
• Molecular Weight: 251.046
• Mol File: 1559077-94-9.mol

Chemical Properties

• CAS DataBase Reference: (E)-1-bromo-3-(3,3,3-trifluoroprop-1-en-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-bromo-3-(3,3,3-trifluoroprop-1-en-1-yl)benzene(1559077-94-9)
• EPA Substance Registry System: (E)-1-bromo-3-(3,3,3-trifluoroprop-1-en-1-yl)benzene(1559077-94-9)

Safety Data

• Hazardous Substances Data: 1559077-94-9(Hazardous Substances Data)

Upstream product

• 887144-94-7 Togni's reagent II 
• 14473-91-7 3-bromocinnamic acid 
• 887144-97-0 Togni's reagent 
• 2039-86-3 3-bromostyrene 
• 2314-97-8 iodotrifluoromethane 
• 3132-99-8 m-bromobenzoic aldehyde 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 2926-29-6 Langlois reagent 

Relevant articles and documents

Electrochemical Synthesis Strategy for Cvinyl-CF3 Compounds through Decarboxylative Trifluoromethylation

An efficient decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids using the Langlois reagent as a trifluoromethyl precursor has been achieved by an electro-oxidative strategy. Under catalyst-free and external oxidant-free electrolysis

Iron(III) Porphyrin Catalyzed Olefination of Aldehydes with 2,2,2-Trifluorodiazoethane (CF3CHN2)

An efficient method for the iron(III) porphyrin catalyzed olefination of various aldehydes with 2,2,2-trifluorodiazoethane under neutral conditions is described. This transformation was shown to have a broad substrate scope and provide the corresponding CF3-substituted alkenes in good yields. The number of equivalents of PPh3 that is used in this reaction is crucial to the success of the olefination process. This reaction is a useful supplement to the synthetic applications of CF3CHN2.

Practical Photocatalytic Trifluoromethylation and Hydrotrifluoromethylation of Styrenes in Batch and Flow

Styrenes represent a challenging class of substrates for current radical trifluoromethylation and hydrotrifluoromethylation methods due to a myriad of potential side reactions. Herein, we describe the development of mild, selective and broadly applicable photocatalytic trifluoromethylation and hydrotrifluoromethylation protocols for these challenging substrates. The methods use fac-Ir(ppy)3, visible light and inexpensive CF3I and can be applied to a diverse set of vinylarene substrates. The use of continuous-flow photochemical reaction conditions allowed to reduce the reaction time and increase the reaction selectivity.

Room temperature decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids by photoredox catalysis

A visible-light-induced decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids, which uses the Togni reagent as the CF3 source is disclosed. The corresponding trifluoromethylated alkenes were obtained in moderate to high yields with excellent functional group tolerance at ambient temperature. Preliminary mechanistic analyses suggest a radical-type mechanism. The Royal Society of Chemistry 2014.

Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent

An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields. The results provided a versatile approach for the construction of Cvinyl-CF3 bonds without using prefunctionalized substrates.