155908-58-0

Basic information

• Product Name: 3-(2,2,2-trifluoroethoxy)benzaldehyde
• Synonyms: 3-(2,2,2-trifluoroethoxy)benzaldehyde;benzaldehyde, 3-(2,2,2-trifluoroethoxy)-
• CAS NO: 155908-58-0
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.1458896
• Mol File: 155908-58-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 230.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.292±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-(2,2,2-trifluoroethoxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,2,2-trifluoroethoxy)benzaldehyde(155908-58-0)
• EPA Substance Registry System: 3-(2,2,2-trifluoroethoxy)benzaldehyde(155908-58-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 155908-58-0(Hazardous Substances Data)

Upstream product

• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 100-83-4 meta-hydroxybenzaldehyde 
• 587-04-2 m-Chlorobenzaldehyde 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 

Downstream Products

• 263349-56-0 (3-phenoxy-phenyl)-[3-(2,2,2-trifluoro-ethoxy)-benzyl]-amine 
• 903630-07-9 (3-(2,2,2-trifluoroethoxy)phenyl)methanamine 

Relevant articles and documents

ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS FOR USE IN EPILEPSY OR SEIZURES

The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS

The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

Palladium-Catalyzed 2,2,2-Trifluoroethoxylation of Aromatic and Heteroaromatic Chlorides Utilizing Borate Salt and the Synthesis of a Trifluoro Analogue of Sildenafil

A simple and convenient method was developed for the introduction of a 2,2,2-trifluoroethoxy group to various aromatic and heteroaromatic systems. The novel process utilizes aromatic chlorides as substrates, and tetrakis(2,2,2-trifluoroethoxy) borate salt as an inexpensive and readily available fluoroalkoxy source in a palladium-catalyzed cross-coupling reaction. The power of the developed methodology was demonstrated in the synthesis of a fluorous derivative of Sildenafil.