155912-06-4

Upstream product

• 19005-93-7 1H-indol-2-ylcarboxaldehyde 
• 59473-45-9 2-(chloromethyl)iodobenzene 

Downstream Products

• 1246088-88-9 ethyl 2-{hydroxy[1-(2-iodobenzyl)-1H-indol-2-yl]methyl}acrylate 
• 1246088-87-8 methyl 2-{hydroxy[1-(2-iodobenzyl)-1H-indol-2-yl]methyl}acrylate 
• 155912-07-5 ethyl 1-(2-iodobenzyl)indole-2-propenoate 

Relevant academic research and scientific papers

Morita-Baylis-Hillman reaction of indole-2-carboxaldehyde: New vistas for indole-annulated systems

DABCO-mediated Morita-Baylis-Hillman reactions of several 1-substituted-indole-2-carboxaldehydes are disclosed. It was discovered that carboethoxy or tert-butoxycarbonyl groups installed at N-1 undergo cleavage under the reaction conditions to afford 2-su

1-Azatriene cyclisation as a route to annelated pyrido[4,3-b]indoles

Derivatives of indole-3-carbaldehyde oxime have been prepared that bear a carbon-carbon double bond at C-2 and a five- or six-membered ring linking the α-carbon atom of the vinyl group and the indole nitrogen atom. Compound 9, with a five-membered ring linking the two atoms, failed to undergo a cyclisation reaction on heating. However the oximes 16 and 22, with a six-membered ring linking the two atoms, cyclised in boiling toluene. The cyclisation led to the formation of the pyridoindoles 17 and 18, respectively.

ELECTROCYCLIC RING CLOSURE OF 1-AZATRIENES AS A ROUTE TO THE INDOLONAPHTHYRIDINE RING SYSTEM

t-Methods of annelation of indole across the 1- and 2-positions have been explored using both the intramolecular Heck reaction and Dieckmann cyclisation.Two examples 5 and 7 of the title ring system have been produced by the thermal cyclisation of indole-3-carboxaldehyde oximes with an akenyl substituent at C-2.