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155975-72-7

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  • 6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione,1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-

    Cas No: 155975-72-7

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155975-72-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 155975-72-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,9,7 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 155975-72:
(8*1)+(7*5)+(6*5)+(5*9)+(4*7)+(3*5)+(2*7)+(1*2)=177
177 % 10 = 7
So 155975-72-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6?,7+,10?/m0/s1

155975-72-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name CLASTO-LACTACYSTIN β-LACTONE

1.2 Other means of identification

Product number -
Other names clasto-Lactacystin-lactone,Synthetic

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:155975-72-7 SDS

155975-72-7Downstream Products

155975-72-7Relevant articles and documents

Structure-activity relationships of lactacystin, the first non-protein neurotrophic factor [6]

Nagamitsu,Sunazuka,Stump,Obata,Arima,Matsuzaki,Tanaka,Omura

, p. 747 - 748 (1995)

-

An efficient synthesis of lactacystin β-lactone

Donohoe, Timothy J.,Sintim, Herman O.,Sisangia, Leena,Harling, John D.

, p. 2293 - 2296 (2004)

A key step in the synthesis of lactacystin β-lactone (3), an inhibitor of the 20 S proteasome, was the ammonia-free reductive aldol reaction of pyrrole 1 to form 2 with complete anti selectivity. This route to 3 takes just 13 steps (14% overall yield) and allows the late-stage stereoselective introduction of a methyl group at C4, which is crucial for the production of analogues. Boc = tert-butoxycarbonyl.

Application of Two Direct C(sp3)-H Functionalizations for Total Synthesis of (+)-Lactacystin

Yoshioka, Shun,Nagatomo, Masanori,Inoue, Masayuki

, p. 90 - 93 (2015/07/28)

(Figure Presented). Herein, we report a new synthetic route from (S)-pyroglutaminol to (+)-lactacystin, a potent inhibitor of the 20S proteasome. The photoinduced intermolecular C(sp3)-H alkynylation and intramolecular C(sp3)-H acylation chemo- and stereoselectively constructed the tetra- and trisubstituted carbon centers, respectively. The obtained bicycle was transformed into the target compound in a concise manner. The present total synthesis demonstrates the power of the direct C(sp3)-H functionalizations for the assembly of multiple functionalized structures of natural products.

Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin

Hayes, Christopher J.,Sherlock, Alexandra E.,Green, Martin P.,Wilson, Claire,Blake, Alexander J.,Selby, Matthew D.,Prodger, Jeremy C.

, p. 2041 - 2051 (2008/09/19)

(Chemical Equation Presented) An alkylidene carbene 1,5-CH insertion has been used as a key step in an enantioselective total syntheses of omuralide, its C7-epimer, and (+)-lactacystin. An additional noteworthy feature of the synthesis is the use of a nov

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