1087348-18-2

Upstream product

• 1087348-53-5 (S)-tert-butyl 2-cyclopropyl-3,5-dioxopyrrolidine-1-carboxylate 
• 1087348-54-6 (2S,3R)-tert-butyl 2-cyclopropyl-3-hydroxy-5-oxopyrrolidine-1-carboxylate 
• 1087348-58-0 (2S)-tert-butyl 2,5-dicyclopropyl-3-oxopyrrolidine-1-carboxylate 
• 2991-42-6 4-trifluorophenylsulfonyl chloride 
• 1087348-55-7 (2S,3R)-tert-butyl 3-tert-butyldimethylsilyloxy-2-cyclopropyl-5-oxopyrrolidine-1-carboxylate 
• 155976-13-9 (2S)-2-[[(tert-butoxy)carbonyl]amino]-2-cyclopropylacetic acid 
• 1087348-59-1 (2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Relevant academic research and scientific papers

PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE

The invention provides compounds of Formula (I) wherein A, Y, R1, R1a, R2, and R2a are as described in the specification. Compounds of Formula I are useful in treating and/or preventing cognitive disorders, such as Alzheimer ''s disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I), methods of preparing compounds of Formula (I), and methods of treating cognitive disorders, such as Alzheimer''s disease.