156-56-9

Basic information

• Product Name: hypoglycin
• Synonyms: hypoglycin;CYCLOPROPANEPROPIONICACID,ALPHA-AMINO-2-METHYLENE-,L-;HYPOGLYCINA;HYPOGLYCINEA;(1R,αS)-α-Amino-2-methylenecyclopropanepropionic acid;2-Methylenecyclopropanealanine;(2S,4R)-Hypoglycin A;[S-(R*,S*)]-α-AMino-2 -Methylenecyclopropanepropanoic Acid
• CAS NO: 156-56-9
• Molecular Formula: C7H11NO2
• Molecular Weight: 141.17
• Product Categories: Amino Acids & Derivatives
• Mol File: 156-56-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: >200°C (dec.)
• Boiling Point: 258.21°C (rough estimate)
• Flash Point: 116.6°C
• Appearance: /
• Density: 1.1522 (rough estimate)
• Vapor Pressure: 0.0021mmHg at 25°C
• Refractive Index: 1.4300 (estimate)
• Storage Temp.: Refrigerator
• PKA: 2.26±0.10(Predicted)
• CAS DataBase Reference: hypoglycin(CAS DataBase Reference)
• NIST Chemistry Reference: hypoglycin(156-56-9)
• EPA Substance Registry System: hypoglycin(156-56-9)

Safety Data

• Hazardous Substances Data: 156-56-9(Hazardous Substances Data)

Usage

Chemical Properties

White Cyrstalline Solid

Uses

A naturally occurring amino acid found in the Ackee (Blighia sapida), concentrated in the fruit of the plant. It is the causative agent of Jamaican Vomiting Sickness.

Definition

A more potent substance than hypoglycine B that is heat liable and the ripe aril, if cooked, is considered a delicacy.

InChI:InChI=1/C7H11NO2/c1-4-2-5(4)3-6(8)7(9)10/h5-6H,1-3,8H2,(H,9,10)/t5-,6-/m0/s1

Upstream product

• 75-11-6 diiodomethane 
• 18934-86-6 1-Formamino-1,1-bis-(aethoxycarbonyl)-pentadien-(3,4) 
• 144604-85-3 (2S,4RS)-2-hydroxy-4-phenylsulfonyl-5-trimethylsilyl-1-pentyl p-toluenesulfonate 
• 144604-86-4 (2S,4RS)-1,2-epoxy-4-phenylsulfonyl-5-trimethylsilylpentane 
• 139242-83-4 (1R,2RS)-<2-phenylsulfonyl-2-<(trimethylsilyl)methyl>cyclopropyl>methanol 
• 144604-87-5 (3R,6S,2''R)-(+)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-6-<(methylenecyclopropyl)methyl>pyrazin 
• 144604-84-2 (S)-(methylenecyclopropyl)methyl p-toluenesulfonate 
• 139242-82-3 (S)-(+)-(methylenecyclopropyl)carbinol 
• 144604-83-1 (2S,4R) α-<(methylenecyclopropyl)methyl>glycine methyl ester 
• 64-18-6 formic acid 

Downstream Products

• 502-37-4 (S)-2-L-γ-glutamylamino-3-((S)-2-methylene-cyclopropyl)-propionic acid 

Related news

Identification of hypoglycin (cas 156-56-9) A binding adsorbents as potential preventive measures in co‐grazers of atypical myopathy affected horses09/30/2019

Background Intestinal absorption of hypoglycin A (HGA) and its metabolism are considered major prerequisites for atypical myopathy (AM). The increasing incidence and the high mortality rate of AM urgently necessitate new therapeutic and/or preventative approaches.Objectives To identify a substan...detailed

Atypical myopathy‐associated hypoglycin (cas 156-56-9) A toxin remains in sycamore seedlings despite mowing, herbicidal spraying or storage in hay and silage09/29/2019

Background Several pasture management strategies have been proposed to avoid hypoglycin A (HGA) intoxication in horses, but their efficacy has never been investigated.Objectives To evaluate the effect of mowing and herbicidal spraying on HGA content of sycamore seedlings and the presence of HGA ...detailed

Quantification of hypoglycin (cas 156-56-9) A as butyl ester09/28/2019

L-α-amino-methylenecyclopropyl propionic acid (Hypoglycin A, HGA) has been found to be the toxic compound in fruits of the Sapindaceae family causing acute intoxication when ingested as food or feed. Clinical symptoms are consistent with acquired multiple acyl-CoA dehydrogenase deficiency (MADD...detailed

Relevant articles and documents

Asymmetric total synthesis of the individual diastereoisomers of hypoglycin A

The individual diastereoisomers that constitute the unusual methylenecyclopropane containing α-amino acid hypoglycin A have been synthesised utilising the Sharpless epoxidation to permit an asymmetric methylenecyclopropane synthesis.