156048-92-9

Basic information

• Product Name: (3R)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
• CAS NO: 156048-92-9
• Molecular Weight: 202.251
• Mol File: 156048-92-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid(156048-92-9)
• EPA Substance Registry System: (3R)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid(156048-92-9)

Safety Data

• Hazardous Substances Data: 156048-92-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 185815-59-2 3-isobutylglutaric anhydride 
• 145328-03-6 1,5-dimethy 3-isobutylpentanedioate 
• 75143-89-4 5-methyl-3-carboxymethylhexanoic acid 

Relevant articles and documents

CAL-B catalyzed desymmetrization of 3-alkylglutarate: "olefin effect" and asymmetric synthesis of pregabalin

CAL-B catalyzed desymmetrization of prochiral 3-alkylglutaric acid diesters was performed to prepare optically active 3-alkylglutaric acid monoesters bearing various alkyl substituents, including methyl, ethyl, propyl and allyl groups. Allyl esters showed

A process for the preparation of a (S)(+)-3-(aminomethyl)-5-methylhexanoic acid

A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) of formula (I) or a salt thereof, comprising the reaction of a compound of formula (II) with an alcohol ROH, in the presence or absence of enzyme, to give a compound of formula (III) as herein defined the transformation of a compound of formula (III) into a compound of formula (VI) or (VIII) as herein defined, and the subsequent hydrolysis of a compound of formula (VI) or (VIII), to give pregabalin.