156052-68-5Relevant articles and documents
Method for preparing benzamide compound
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Paragraph 0053-0062, (2020/06/30)
The invention provides a method for preparing a benzamide compound, and belongs to the technical field of organic synthesis. The method for preparing a benzamide compound provided by the invention comprises the following steps: mixing aryl-substituted dihydrooxazole, an acidic catalyst, water and a reaction solvent, and carrying out hydrolysis ring-opening reaction to obtain the benzamide compound, wherein the acidic catalyst is p-toluenesulfonic acid or sulfonic acid ion exchange resin. According to the invention, p-toluenesulfonic acid or sulfonic acid ion exchange resin is used as an acidiccatalyst, under the catalytic action of the p-toluenesulfonic acid or sulfonic acid ion exchange resin, aryl-substituted dihydrooxazole is subjected to hydrolysis ring-opening reaction to obtain thebenzamide compound, only metered toluenesulfonic acid or sulfonic acid ion exchange resin needs to be catalyzed, the toluenesulfonic acid or sulfonic acid ion exchange resin is convenient to remove after the reaction is completed, almost no waste is generated, and industrial production is convenient to achieve.
Process for the manufacture of acetonylbenzamides
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, (2008/06/13)
Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.
Development of a process for triazine-promoted amidation of carboxylic acids
Rayle, Heather L.,Fellmeth, Lisa
, p. 172 - 176 (2013/09/08)
A process has been developed for the triazine-promoted amidation of carboxylic acids. We have identified 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) as a cost-effective reagent for this transformation. The procedure is a suitable alternative to traditional amidation processes when an acid chloride cannot be prepared from the corresponding carboxylic acid due to safety, stability, or handling concerns.