82845-85-0 Usage
Uses
Used in Research Applications:
5-Methyl-d3-uridine-6-d1 is used as a labeled compound for research purposes, particularly in the study of RNA structure, function, and dynamics. The incorporation of deuterium isotopes allows for enhanced detection and analysis of the compound using techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.
Used in Diagnostic Applications:
5-Methyl-d3-uridine-6-d1 is used as a biological marker for patients with colorectal cancer. As a primary degradation product of tRNA, its presence in urine can indicate the presence of the disease, providing a non-invasive method for diagnosis and monitoring of the condition.
Used in Drug Development:
5-Methyl-d3-uridine-6-d1 can be used in the development of drugs targeting RNA modifications, such as 5-methyluridine. The labeled compound can be used to study the effects of potential drugs on RNA function and to optimize their efficacy and selectivity.
Used in Biochemical Assays:
5-Methyl-d3-uridine-6-d1 can be used as a substrate or standard in biochemical assays to study the activity of enzymes involved in RNA modification, degradation, or synthesis. The labeled compound can help researchers to better understand the mechanisms of these processes and to identify potential targets for therapeutic intervention.
Check Digit Verification of cas no
The CAS Registry Mumber 82845-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,8,4 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 82845-85:
(7*8)+(6*2)+(5*8)+(4*4)+(3*5)+(2*8)+(1*5)=160
160 % 10 = 0
So 82845-85-0 is a valid CAS Registry Number.
82845-85-0Relevant articles and documents
Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides
Taniguchi, Yosuke,Cao, Xiuming,Sasaki, Shigeki
, (2019)
The efficient synthesis of the highly-deuterated thymidine-d9 by the glycosylation reaction between a deuterated nucleobase and deuterated sugar is described. It is also incorporated into the oligonucleotides using a DNA synthesizer. Using this
