156072-86-5

Basic information

• Product Name: 5-bromo-3-methylpicolinonitrile
• Synonyms: 5-bromo-3-methylpicolinonitrile;5-Bromo-2-cyano-3-methylpyridine, 5-Bromo-3-methylpicolinonitrile;5-BroMo-2-cyano-3-Methylpyridine;2-Pyridinecarbonitrile,5-bromo-3-methyl-
• CAS NO: 156072-86-5
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.032
• Mol File: 156072-86-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 283.6 °C at 760 mmHg
• Flash Point: 125.3 °C
• Appearance: /
• Density: 1.61 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -2.38±0.20(Predicted)
• CAS DataBase Reference: 5-bromo-3-methylpicolinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-methylpicolinonitrile(156072-86-5)
• EPA Substance Registry System: 5-bromo-3-methylpicolinonitrile(156072-86-5)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 156072-86-5(Hazardous Substances Data)

Usage

General Description

5-bromo-3-methylpicolinonitrile is a chemical compound with the molecular formula C7H6BrN2. It is a derivative of picolinonitrile and contains a bromine atom and a methyl group. This chemical is commonly used in the synthesis of pharmaceuticals and other organic compounds. It is also used as a building block in the production of various functional materials and agrochemicals. 5-bromo-3-methylpicolinonitrile is a valuable reagent in organic chemistry and is known for its diverse reactivity and potential applications in the field of drug discovery and material science.

Upstream product

• 3430-18-0 2,5-dibromo-3-methylpyridine 
• 544-92-3 copper(I) cyanide 
• 3430-21-5 5-bromo-3-methyl-pyridin-2-ylamine 
• 20970-75-6 2-cyano-3-methylpyridine 
• 252056-70-5 5-amino-3-methylpyridine-2-carbonitrile 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 65169-63-3 3-methyl-5-nitropyridine-2-carbonitrile 

Downstream Products

• 1260670-05-0 3-bromo-8-chloro-[1,7]naphthyridine 
• 1400645-41-1 5-bromo-3-methyl-pyridine-2-carboxylic acid amide 
• 1849594-85-9 C₉H₁₀BrNO₃ 
• 794592-13-5 5-bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester 
• 1048678-16-5 (3-{7-oxo-6-[4-(trifluoromethoxy)benzyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl}phenyl)formamide 
• 1048678-22-3 3-bromo-6-[4-(trifluoromethoxy)benzyl]-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 
• 1375301-90-8 3-bromo-7H-[1,7]naphthyridin-8-one 
• 1600511-75-8 8-chloro-3-methoxy-1,7-naphthyridine 
• 1569695-13-1 C₉H₈N₂O₂ 
• 1256792-17-2 (5-methoxy-3-methylpyridin-2-yl)methanamine 

Relevant articles and documents

Design, synthesis and biological evaluation of pyridone–aminal derivatives as MNK1/2 inhibitors

Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on Ser209. So, MNK1/2 inhibitors could decrease the level of p-eIF4E and regulate tumor-associated signaling pathways. A series of pyridone–aminal derivatives were synthesized and evaluated as MNK1/2 inhibitors. Several compounds exhibited great inhibitory activity against MNK1/2 and selected compounds showed moderate to excellent anti-proliferative potency against hematologic cancer cell lines. In particular, compound 42i (MNK1 IC50 = 7.0 nM; MNK2 IC50 = 6.1 nM) proved to be the most potent compound against TMD-8 cell line with IC50 value of 0.91 μM. Furthermore, 42i could block the phosphorylation level of eIF4E in CT-26 cell line, and 42i inhibited the tumor growth of CT-26 allograft model significantly. These results indicated that compound 42i was a promising MNK1/2 inhibitor for the potent treatment of colon cancer.

Novel compounds

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

Synthesis and Properties of a Novel Pyridineoxazoline Containing Optically Active Helical Polymer as a Catalyst Ligand for Asymmetric Diels-Alder Reaction

A novel pyridineoxazoline (PyOx) containing helical polymer, poly{(-)-(S)-4-tert-butyl-2-[5-(4-tert-butylphenyl)-3-vinylpyridin-2-yl]-oxazoline} (PA), was designed and synthesized to approach the effect of chain conformation on the catalytic property. Its