156095-82-8Relevant articles and documents
Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase
Buurman, Ed T.,Blodgett, April E.,Hull, Kenneth G.,Carcanague, Daniel
, p. 313 - 318 (2004)
The first step in ergosterol biosynthesis in Saccharomyces cerevisiae consists of the condensation of two acetyl coenzyme A (acetyl-CoA) moieties by acetoacetyl-CoA thiolase, encoded by ERG10. The inhibition of the sterol pathway results in feedback activ