1561048-71-2Relevant academic research and scientific papers
Direct synthesis of 2-deoxy-β-glycosides via anomeric O-alkylation with secondary electrophiles
Zhu, Danyang,Baryal, Kedar N.,Adhikari, Surya,Zhu, Jianglong
supporting information, p. 3172 - 3175 (2014/03/21)
An approach for direct synthesis of biologically significant 2-deoxy-β-glycosides has been developed via O-alkylation of a variety of 2-deoxy-sugar-derived anomeric alkoxides using challenging secondary triflates as electrophiles. It was found a free hydroxyl group at C3 of the 2-deoxy-sugar-derived lactols is required in order to achieve synthetically efficient yields. This method has also been applied to the convergent synthesis of a 2-deoxy-β-tetrasaccharide.
