156152-25-9

Upstream product

• 67-56-1 methanol 
• 156152-11-3 1-phenyl-3-carboxy-6-naphthol 
• 132725-90-7 7-methoxy-4-phenyl-2-naphthoic acid 

Downstream Products

• 1160271-25-9 4-phenyl-7-[(2,3,6-trichlorobenzyl)oxy]-2-naphthoic acid 
• 156151-06-3 4-[3-(7-Hydroxymethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol 
• 158741-37-8 4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol 
• 181275-69-4 7-(1-Methyl-1H-tetrazol-5-yl)-5-phenyl-naphthalen-2-ol 
• 181275-68-3 7-(2-Methyl-2H-tetrazol-5-yl)-5-phenyl-naphthalen-2-ol 
• 181275-66-1 5-Phenyl-7-(1H-tetrazol-5-yl)-naphthalen-2-ol 
• 156152-32-8 1-phenyl-3-chloromethyl-6-naphthol 
• 156152-27-1 1-phenyl-3-cyano-6-naphthol 
• 181275-65-0 1-Phenyl-3-hydroxymethyl-6-naphthol 
• 156152-04-4 7-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-benzyloxy]-4-phenyl-naphthalene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: Structure-activity relationship study directed toward the improvement of metabolic stability

Naphthalenic lignan lactone 3a (L-702,539), a potent and selective 5- 1ipoxygenase (5-LO) inhibitor, is extensively metabolized at two different sites: the tetrahydropyran and the lactone rings. Early knowledge of the metabolic pathways triggered and directed a structure-activity relationship study aimed toward the improvement of metabolic stability in this series. The best modifications discovered, i.e., replacement of the lactone ring by a nitrile group, replacement of the tetrahydropyran ring by a 6,8- dioxabicyclo[3.2.1]octanyl moiety, and replacement of the pendant phenyl ring by a 3-furyl ring, were incorporated in a single molecule to produce inhibitor 9ac (L-708,780). Compound 9ac inhibits the oxidation of arachidonic acid to 5-hydroperoxyeicosatetraenoic acid by 5-LO (IC50 = 190 nM) and the formation of leukotriene B4 in human polymorphonuclear leukocytes (IC50 = 3 nM) as well as in human whole blood (IC50 = 150 nM). The good inhibitory profile shown by naphthalenenitrile 9ac is accompanied by an improved resistance to oxidative metabolism. In addition, 9ac is orally active in the functional model of antigen-induced bronchoconstriction in allergic squirrel monkeys (95% inhibition at 0.1 mg/kg).

Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis

Compounds having the formula I: STR1 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.