156152-95-3

Upstream product

• 156152-89-5 phenyl 2,4,5-trifluorobenzoate 
• 156152-90-8 2-nitro-1-(2,4,5-trifluorophenyl)ethanone 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 367-25-9 2,4-difluorophenylamine 

Downstream Products

• 156152-92-0 1-(2,4-difluorophenyl)-6,7-difluoro-3-nitroquinolin-4(1H)-one 

Relevant academic research and scientific papers

Synthesis of 1-substituted 3-nitroquinolin-4(1H)-ones

A versatile synthetic method for preparing 1-substituted 3-nitroquinolin-4(1H)-ones from corresponding 2-fluoro-α-nitroacetophenones is demonstrated by the synthesis of 6,7-difluoro derivatives 7a-c. The method involves sequential treatment of the starting nitroacetophenone with triethyl orthoformate and the appropriate amine, followed by a nucleophilic cyclization reaction under mild conditions. The C-7 fluorine atom of 7 can be displaced by cyclic amines. Substituted 6-fluoro-7-(4-methy)-1-piperazinyl)-3-nitroquinolin-4(1H)-ones 8a-c were prepared in this way.