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1561810-43-2

N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1561810-43-2 Structure

  • Basic information

    1. Product Name: N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide
    2. Synonyms: N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide
    3. CAS NO:1561810-43-2
    4. Molecular Formula:
    5. Molecular Weight: 471.949
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1561810-43-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide(1561810-43-2)
    11. EPA Substance Registry System: N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide(1561810-43-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1561810-43-2(Hazardous Substances Data)

1561810-43-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1561810-43-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,6,1,8,1 and 0 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1561810-43:
(9*1)+(8*5)+(7*6)+(6*1)+(5*8)+(4*1)+(3*0)+(2*4)+(1*3)=152
152 % 10 = 2
So 1561810-43-2 is a valid CAS Registry Number.

1561810-43-2Relevant articles and documents

Heterocyclic amines Hedgehog signal pathway inhibitor

-

, (2017/10/06)

The invention relates to the field of biological medicine, in particular to a heterocyclic amine compound and an application thereof, namely a general formula (I) compound and acceptable salt in the pharmaceutical field. The compound can be used in the Hedgehog signal transduction inhibitor application and various medical applications (please see the formula in the specification). The invention further relates to a preparation method with the general formula (I).

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors

Xin, Minhang,Zhang, Liandi,Tang, Feng,Tu, Chongxing,Wen, Jun,Zhao, Xinge,Liu, Zhaoyu,Cheng, Lingfei,Shen, Han

, p. 1429 - 1440 (2014/03/21)

A novel series of Hh signaling pathway inhibitors were designed by replacing the pyrimidine skeleton of our earlier reported lead compound 1 with pyrrolo[2,1-f][1,2,4]triazine scaffold. Starting from this new scaffold, SAR exploration was investigated based on structural modification on A-ring, C-ring and D-ring. And several much potent compounds were studies in vivo to profile their pharmacokinetic properties. Finally, optimization leads to the identification of compound 19a, a potent Hh signaling pathway inhibitor with superior potency in vitro and satisfactory pharmacokinetic properties in vivo.

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