15619-19-9

Usage

Uses

Used in Pharmaceutical Research:
4α-tert-Butylcyclohexane-1α-carbonitrile is used as a precursor in the development of various pharmaceuticals for its ability to be chemically modified and incorporated into the structures of potential drugs.
Used in Agrochemical Production:
In the agrochemical industry, 4α-tert-Butylcyclohexane-1α-carbonitrile is used as a starting material for synthesizing compounds that have applications in crop protection and pest control, contributing to the development of effective and targeted agrochemicals.
It is crucial to handle 4α-tert-Butylcyclohexane-1α-carbonitrile with care and adhere to proper safety protocols due to its reactivity and potential hazards associated with cyanide-containing compounds.

Upstream product

• 61827-31-4 1-(1-Cyano-4-tert-butylcyclohexyl)-2-carbomethoxyhydrazine 
• 83859-38-5 carbomethoxyhydrazone of 4-tert-butylcyclohexanone 
• 143-33-9 sodium cyanide 
• 20691-52-5 1-carboxaldehyde-4-(1,1-dimethylethyl)-cyclohexane 
• 7453-05-6 toluene-4-sulfonic acid-(trans-4-tert-butyl-cyclohexyl ester) 
• 33670-05-2 C₁₃H₂₁N₃O₂ 

Relevant academic research and scientific papers

DIASTEREOSELECTIVE PROTONIERUNG VON CARBANIONEN

Despite of very small side differentiation in 3-Li the ratio of cis-3: trans-3 can be shifted from 41: 59 to 85: 15 by variation of the proton sources.

OXIDATIVE CONVERSION OF ALIPHATIC ALDEHYDES TO NITRILES USING OXOAMMONIUM SALT

The present invention relates to an oxidative transformation method of aliphatic benzaldehydes to nitriles using NH_4OAc through oxoammonium salts. By using stoichiometric amounts of oxoammonium salts to establish optimal reaction conditions associated with the oxidative conversion of aliphatic benzaldehydes to nitriles, high yields of nitrile can be selectively obtained, and the oxoammonium salts used can be oxidized and reused in a simple method.COPYRIGHT KIPO 2020

Oxoammonium salt-mediated oxidative nitriles synthesis from aldehydes with ammonium acetate

An efficient and scalable route for the synthesis of nitriles was developed by oxoammonium salt (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) mediated oxidative conversion of aldehydes with NH4OAc. A variety of aliphatic aldehydes as well as benzaldehydes were converted into the corresponding nitriles in high yields. The nitroxyl radical which is the reduced species of the used oxoammonium salt was recovered by simple acid-base extraction for the recycling.

Stereoselective Protonation of Carbanions, 1. - Diastereoselective Protonation of C-H-Activated Cyclohexane Derivatives

The diastereoselectivity of the kinetically controlled protonation of carbanions derived from 4-tert-butyl-1-X-cyclohexanes (1: X = CN, 2: X = CO2Me, 2-Si: X = C(OMe)OSiMe3, 3: X = COPh, 4: X = SO2Ph) is systematically investigated.By variation of (a) the

The Stereochemistry of Organometallic Compounds. XXII The Stereochemistry of Metal-Catalysed Hydrogen Cyanide Addition to Olefins

Reactions of (E)-3,3-dimethyl(1,2-D2)but-1-ene with hydrogen cyanide and of (E)-3,3-dimethyl(1-D)but-1-ene with deuterium cyanide have been shown to proceed in a completely stereospecific cis fashion when a catalyst system based on Pd(diop)2 was used.Reaction between 4-t-butylcyclohexene and deuterium cyanide with the catalyst system gave only the equatorial nitriles trans-4-t-butylcyclohexane-1-carbonitrile and cis-3-t-butylcyclohexane-1-carbonitrile with cis incorporation of deuterium.Use of a catalyst system based on Ni4 and zinc chloride led to significant amounts of isotopic exchange and rearrangement.These results are compared with those from hydroformylation of the olefins, and the mechanism of hydrocyanation is discussed