20691-52-5

Usage

Uses

Used in the Food Industry:
4-tert-Butylcyclohexanecarbaldehyde serves as a flavoring agent, contributing to the enhancement of food products' aroma and taste profiles. Its strong odor makes it a valuable component in creating complex and appealing flavor profiles in a variety of food items.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 4-tert-Butylcyclohexanecarbaldehyde is utilized as a key intermediate in the synthesis of various organic compounds and pharmaceuticals. Its chemical reactivity allows for the creation of a wide range of medicinal agents, contributing to the development of new drugs and therapies.
Used in Organic Chemistry:
4-tert-Butylcyclohexanecarbaldehyde is employed as a versatile reagent in organic chemistry due to its ability to participate in numerous chemical reactions. This makes it instrumental in the synthesis of a broad spectrum of organic compounds for research and industrial applications.
Used in Fragrance Industry:
The strong odor of 4-tert-Butylcyclohexanecarbaldehyde also makes it suitable for use in the fragrance industry, where it can be incorporated into perfumes, colognes, and other scented products to provide unique and desirable olfactory characteristics.
Safety Considerations:
Given its flammability and potential hazards, 4-tert-Butylcyclohexanecarbaldehyde must be handled with appropriate safety measures in place. This includes proper storage, use of protective equipment, and adherence to safety protocols to minimize risks associated with its use.

InChI:InChI=1/C11H20O/c1-11(2,3)10-6-4-9(8-12)5-7-10/h8-10H,4-7H2,1-3H3

Upstream product

• 201230-82-2 carbon monoxide 
• 2228-98-0 4-tert-butylcylohexene 
• 113388-53-7 Formic acid 4-tert-butyl-cyclohexylidenemethyl ester 
• 60-29-7 diethyl ether 
• 20691-53-6 (4-(tert-butyl)cyclohexyl)methanol 
• 5451-55-8 4-tert-butylcyclohexanecarboxylic acid 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 56300-88-0 2-(4-tert-butylcyclohexylidene)acetaldehyde 
• 110166-50-2 2-(4-tert-Butyl-cyclohexyl)-benzo[1,3]dithiole 
• 63830-88-6 4-t-Butylcyclohexan-1-oxiran-2-ylmethyltrimethylsilane 

Downstream Products

• 15619-18-8 trans-4-tert-Butylcyclohexanecarbonitrile 
• 15619-19-9 cis-4-tert-Butylcyclohexanecarbonitrile 
• 31865-37-9 cis/trans-4-tert-Butylcyclohexancarbonitril 

Relevant academic research and scientific papers

Method for reducing carboxylic acid into aldehyde compounds

The invention discloses a method for reducing carboxylic acid into aldehyde compounds, and belongs to the field of organic chemical synthesis. Specifically, in an argon atmosphere, a carboxylic acid compound, a transition metal nickel compound, an anhydride compound, a ligand and a reducing agent are dissolved in an organic solvent, the mixture is heated and subjected to stirring reaction, after the reaction is finished, the pressure is reduced to remove the organic solvent, column chromatography separation is performed, and various aldehyde compounds are obtained. The method has the advantages of simple synthesis steps, mild reaction conditions, simplicity and easiness in operation, realization of successful reduction of the carboxylic acid compound into the aldehyde organic compounds, small use amount of the reaction catalyst, high product yield, and provision of a new approach for reduction of the carboxylic acid compound into the aldehyde compounds. Compared with a conventional method, the method has the advantages that raw materials are cheap, easy to obtain and environmentally friendly, substrate universality and functional group compatibility are improved, and the method hascertain innovativeness and unique research significance in organic synthesis methodology.

CCK ANALOGS WITH APPETITE REGULATING ACTIVITY

The invention is directed to novel CCK analogs wherein Tryptophan and/or Phenylalamine are substituted with a radical which provides enhanced appetite suppressant activity to the peptide.

A New Synthetic Application of 1,2-Benzodithiolium Cations: Synthesis of Aldehydes by 1-Carbon Homologation of Carbonyl Compounds

Eleven aldehydes (6a-l) were synthesized by 1-carbon homologation of ketones and aldehydes according to the following sequence: Horner-Emmons reaction of 2-(O,O-dimethylphosphonyl)-1,3-benzodithiole (1) and various carbonyl compounds (2) to give benzo-1,4-dithiafulvenes (3); reduction with sodium borohydride and tetrafluoroboric acid-ether complex in dry acetonitrile to 1,3-benzodithioles (5); subsequent hydrolysis of these with mercury(II)oxide and aqueous tetrafluoroboric acid (35percent) in tetrahydrofuran.The procedure is simple, of wide application, and afforded pure aldehydes in good overall yields (55-88percent).

REACTION OF α,β-UNSATURATED ALDEHYDES WITH HYDROGEN PEROXIDE CATALYSED BY BENZENESELENINIC ACIDS AND THEIR PRECURSORS

Oxidation of α,β-unsaturated aldehydes with hydrogen perixide catalysed by benzeneselenic acids and their precursors has been investigated.Bis 2-nitrophenyl diselenide has proved to be the most effective catalyst.The major products resulting from the oxidation are vinyl formates (a) which on hydrolysis give saturated aldehydes or ketones (g) having the carbon chain shortened by one carbon atom, compared with the starting aldehydes.The minor products are formyloxyoxiranes (b), α-hydroxycarbonyl (e) and α-formyloxycarbonyl (f) compounds with the carbon chain shortened by one carbon atom.Carbonyl compounds d, formally derived from an oxidative fission of the carbon-carbon double bond, have been also isolated.Diformyloxy (4c) and formyloxyacetoxy phenylmethane (5c) have been isolated when cinnamaldehyde (4) or 1-phenyl-2-formyloxypropane (5a) were oxidized, respectively.Possible mechanisms of formation of these products are discussed.Similar products resulted when α,β-unsaturated aldehydes were oxidized with organic peroxy acids.

SILICON IN SYTHESIS-17 CHLROMETHYL(TRIMETHYLSILYL)LITHIUM-A NEW REAGENT FOR THE DIRECT CONVERSION OF ALDEHYDES AND KETONES INTO α,β-EPOXYTRIMETHYLSILANES

Treatment of chloromethyltrimethylsilane 1 with sec-BuLi at -78 deg produces chloromethyl(trimethylsilyl)lithium 4.Treatment of 4 with a wide range of aldehydes and ketones gives α,β-epoxytrimethylsilanes 5-28, which on acidic hydrolysis give homologated aldehydes.

The Stereochemistry of Organometallic Compounds. XXII The Stereochemistry of Metal-Catalysed Hydrogen Cyanide Addition to Olefins

Reactions of (E)-3,3-dimethyl(1,2-D2)but-1-ene with hydrogen cyanide and of (E)-3,3-dimethyl(1-D)but-1-ene with deuterium cyanide have been shown to proceed in a completely stereospecific cis fashion when a catalyst system based on Pd(diop)2 was used.Reaction between 4-t-butylcyclohexene and deuterium cyanide with the catalyst system gave only the equatorial nitriles trans-4-t-butylcyclohexane-1-carbonitrile and cis-3-t-butylcyclohexane-1-carbonitrile with cis incorporation of deuterium.Use of a catalyst system based on Ni4 and zinc chloride led to significant amounts of isotopic exchange and rearrangement.These results are compared with those from hydroformylation of the olefins, and the mechanism of hydrocyanation is discussed