1561996-79-9Relevant academic research and scientific papers
Regioselective synthesis of 9,10-dihydro-6H-chromeno[4,3-d]imidazo-[1,2-a] pyridin-6-one derivatives
Yu, Fu-Chao,Chen, Zhi-Qiong,Hao, Xiao-Pan,Yan, Sheng-Jiao,Huang, Rong,Lin, Jun
, p. 6110 - 6115 (2014/01/23)
A method for regioselective synthesis of 9,10-dihydro-6H-chromeno[4,3-d] imidazo[1,2-a]pyridin-6-one derivatives has been developed. The reaction was readily performed by reacting inexpensive materials, 4-chloro-3-formylcoumarin and HKAs, in EtOH catalyzed by Et3N. This protocol has many advantages including convenient operation, short reaction times, green solvent, and simple purification by washing the crude products with 95% EtOH, defined as GAP (Group-Assistant-Purification) chemistry. The library of 9,10-dihydro-6H-chromeno[4,3-d]imidazo[1,2-a]pyridin-6-one derivatives has been constructed with excellent yields.
