1256150-86-3

Upstream product

• 107-15-3 ethylenediamine 
• 50850-02-7 3,3-Dimercapto-1-o-chlorphenyl-2-propen-1-on 
• 56944-67-3 1-(2-chlorophenyl)-3,3-bis(methylthio)prop-2-en-1-one 

Downstream Products

• 1631146-69-4 1-(2-chlorophenyl)-2-(imidazolidin-2-ylidene)-2-(phenylthio)ethan-1-one 
• 1634693-15-4 (Z)-6-bromo-3-(3-(2-chlorophenyl)-2-(imidazolidin-2-ylidene)-3-oxopropylidene)chroman-2,4-dione 
• 1634693-11-0 (Z)-3-(3-(2-chlorophenyl)-2-(imidazolidin-2-ylidene)-3-oxopropylidene)chroman-2,4-dione 
• 1561996-79-9 12-(2-chlorobenzoyl)-9,10-dihydro-6H-chromeno[4,3-d]imidazo[1,2-a]pyridin-6-one 
• 1463517-98-7 (4Z)-4-(3-(2-chlorophenyl)-2-(imidazolidin-2-ylidene)-3-oxopropylidene)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one 
• 1463517-85-2 (4Z)-4-(3-(2-chlorophenyl)-2-(imidazolidin-2-ylidene)-3-oxopropylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one 
• 1450991-98-6 C₂₀H₁₇ClN₂O₂ 
• 1401457-58-6 6-(4-chlorophenyl)-4-methyl-7-oxo-N-phenyl-1,2,6,7-tetrahydrobenzo[b]imidazo[1,2,3-ij][1,8]naphthyridine-5-carboxamide 
• 1401457-39-3 8-(2-chlorobenzoyl)-7-(4-chlorophenyl)-5-methyl-N-phenyl-1,2,3,7-tetrahydroimidazo[1,2-a]pyridine-6-carboxamide 
• 1291073-64-7 5-benzyl-6-methyl-1,2-dihydro-4H,7H-benzo[b]imidazo[1,2,3-ij][1,8]naphthyridine-4,7-dione 
• 1291073-42-1 6-benzyl-8-(2-chlorobenzoyl)-7-methyl-2,3-dihydroimidazo[1,2-a]pyridin-5(1H)-one 

Relevant academic research and scientific papers

Multicomponent Tether Catalysis Synthesis of Highly Functionalized 4-(Pyridin-2-ylmethyl)-2-aminopyrroles via Cascade Reaction Is Accompanied by Decarboxylation

A multicomponent tether catalysis protocol for the synthesis of 4-(pyridin-2-ylmethyl)-2-aminopyrroles (PMAPs) was constructed by simply refluxing a mixture of ethyl 2-(pyridin-2-yl)acetates 1 and various types of arylglyoxal monohydrates 2 and different heterocyclic ketene aminals 3 in EtOH solvent. Based on this reaction, a series of highly functionalized PMAPs were obtained through a novel cascade reaction accompanied by a decarboxylation mechanism. As a result, the pyridin-2-ylmethyl was successfully introduced in the target compounds, and a library of PMAPs were easily constructed using the cascade reaction described in this study. This protocol demonstrated that the most important feature was the decarboxylation reaction of the 2-(pyridin-2-yl)acetates 1, which can be used in the synthesis of pyridin-2-ylmethyl-substituted heterocycles, including pyrroles, pyridines, quinolones, and other heterocyclic compounds resembling those found in nature.

Synthesis of imidazo[1,2-a]pyridines and pyrido[1,2-a]pyrimidines in water and their snar cyclizations

Synthesis of tetrahydroimidazo[1,2-a]pyridines and tetrahydropyrido[1,2-a] pyrimidines by a one-pot and three component reaction of α-oxoketenedithioacetals, diamines and DMAD in water has been described. Different routes for accessing the desired compoun