1562-95-4Relevant articles and documents
Synthesis and transition metal coordination chemistry of a novel hexadentate bispidine ligand
Comba, Peter,Rudolf, Henning,Wadepohl, Hubert
, p. 2724 - 2736 (2015)
Reported is the new bispidine-derived hexadentate ligand L (L = 3-(2-methylpyridyl)-7-(bis-2-methylpyridyl)-3,7-diazabicyclo[3.3.1]nonane) with two tertiary amine and four pyridine donor groups. This ligand can form heterodinuclear and mononuclear complexes and, in the mononuclear compounds discussed here, the ligand may coordinate as a pentadentate ligand, with one of the bispyridinemethane-based pyridine groups un- or semi-coordinated, or as a hexadentate ligand, leading to a pentagonal pyramidal coordination geometry or, with an additional monodentate ligand, to a heptacoordinate pentagonal bipyramidal structure. The solution and solid state data presented here indicate that, with the relatively small CuII and high-spin FeII ions the fourth pyridine group is only semi-coordinated for steric reasons and, with the larger high-spin MnII ion genuine heptacoordination is observed but with a relatively large distortion in the pentagonal equatorial plane. This journal is
Hybrid organic-inorganic materials from di-(2-pyridyl)methylamine-palladium dichloride complex as recoverable catalysts for Suzuki, Heck and Sonogashira reactions
Trilla, Montserrat,Pleixats, Roser,Man, Michel Wong Chi,Bied, Catherine,Moreau, Joel J. E.
, p. 577 - 590 (2008)
Hybrid silica materials containing the di-(2-pyridyl)methylamine-palladium dichloride complex, prepared by sol-gel cogelification, are efficient recyclable catalysts for Suzuki (aryl bromides and chlorides), Heck (aryl bromides) and Sonogashira reactions (aryl iodides and bromides). Formation of palladium(0) nanoparticles is observed in the Suzuki and Heck reactions but not in the Sonogashira coupling.
Interplay Between Steric and Electronic Effects: A Joint Spectroscopy and Computational Study of Nonheme Iron(IV)-Oxo Complexes
Mukherjee, Gourab,Alili, Aligulu,Barman, Prasenjit,Kumar, Devesh,Sastri, Chivukula V.,de Visser, Sam P.
, p. 5086 - 5098 (2019)
Iron is an essential element in nonheme enzymes that plays a crucial role in many vital oxidative transformations and metabolic reactions in the human body. Many of those reactions are regio- and stereospecific and it is believed that the selectivity is guided by second-coordination sphere effects in the protein. Here, results are shown of a few engineered biomimetic ligand frameworks based on the N4Py (N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) scaffold and the second-coordination sphere effects are studied. For the first time, selective substitutions in the ligand framework have been shown to tune the catalytic properties of the iron(IV)-oxo complexes by regulating the steric and electronic factors. In particular, a better positioning of the oxidant and substrate in the rate-determining transition state lowers the reaction barriers. Therefore, an optimum balance between steric and electronic factors mediates the ideal positioning of oxidant and substrate in the rate-determining transition state that affects the reactivity of high-valent reaction intermediates.
Aromatic-ring-containing compound, preparation method thereof, pharmaceutical composition and application thereof
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Paragraph 0602-0606, (2018/08/03)
The invention discloses an aromatic-ring-containing compound, a preparation method thereof, a pharmaceutical composition and application. The present invention provides the aromatic-ring-containing compound represented by a formula 1, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or a solvate thereof, and the aromatic-ring-containing compound can be effectively bounded to bromodomains of BRD4, BRD3, BRD2, and BRDT in BET family to regulate transcription of downstream gene c-myc and related target genes of the c-myc so as to regulate downstream signalingpathways to play specific roles including treatment of diseases such as inflammatory diseases, cancer, and AIDS. Some of the compounds have high activity, and have good cell activity and metabolic stability, so that the compounds can be an effective drug for treating tumors.
