156207-54-4

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 439917-15-4 (22β,25R)-3β,26-dihydroxyfurost-5-en-3β-acetate 
• 1061-54-7 diosgenin acetate 
• 512-04-9 diosgenin 

Downstream Products

• 695226-35-8 (22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(2,4-dinitrobenzoyloxy)cholesta-5,17(20)-diene 
• 695226-31-4 (22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene 
• 695226-37-0 (20R)-3β-acetoxy-16β-(2,4-dinitrobenzoyloxy)-20,22-epoxycholesta-5-ene-17α-ol 
• 695226-36-9 (22R)-3β-acetoxy-16β-(2,4-dinitrobenzoyloxy)cholesta-5,17(20)-diene-22-ol 
• 695226-34-7 (20S,22R)-3β-acetoxy-17α-hydroxycholesta-5-ene-16β,20,22-ortho-4-nitrobenzoate 
• 695226-33-6 (20R)-3β-acetoxy-16β-(4-nitrobenzoyloxy)-20,22-epoxycholesta-5-ene-17α-ol 
• 695226-32-5 (22R)-3β-acetoxy-16β-4-nitrobenzoyloxycholesta-5,17(20)-diene-22-ol 

Relevant academic research and scientific papers

A Novel Synthetic Approach from Diosgenin to a 17α-Hydroxy Orthoester via a Regio- and Stereo-Specific Rearrangement of an Epoxy Ester

A cholesterol model compound, containing 16β-acetoxy, 17α-hydroxy, and (20S, 22R)-epoxy groups was synthesized from diosgenin in 13 steps and was rearranged regio- and stereo-specifically to an orthoester with BF3-Et2O.

Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate

Solasodine acetate, an anticancer steroidal alkaloid, was synthesized from diosgenin in 8 steps with an overall yield of 23%. A key synthetic step involves the formation of 5/6-oxazaspiroketal moiety via hypoiodite-mediated aminyl radical cyclization of a steroidal primary amine.