1562305-77-4Relevant articles and documents
Solvent-free Br?nsted acid catalysed alkylation of arenes and heteroarenes with benzylic alcohols
Barbero, Margherita,Cadamuro, Silvano,Dughera, Stefano,Rucci, Marta,Spano, Giulia,Venturello, Paolo
, p. 1818 - 1826 (2014)
A simple and efficient alkylation of aromatic and heteroaromatic compounds via the direct SN1-type nucleophilic substitution of benzylic alcohols in the presence of catalytic amounts of the strong Br?nsted acid o-benzenedisulfonimide under neat conditions is herein reported. A library of di- and triaryl (and heteroaryl) methanes was prepared in good yields and high regioselectivity. The observed reactivity was shown to be in agreement with Mayr's nucleophilicity and electrophilicity scales.