7494-77-1

Usage

Uses

Used in Pharmaceutical Industry:
4-(DIMETHYLAMINO)BENZHYDROL is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drug molecules. Its unique chemical structure allows it to be incorporated into a variety of medicinal compounds, enhancing their therapeutic properties and effectiveness.
Used in Cosmetic Industry:
In the cosmetic industry, 4-(DIMETHYLAMINO)BENZHYDROL is utilized as an ingredient in the formulation of various cosmetic products. Its mild aromatic odor and low toxicity make it suitable for use in fragrances, creams, and other personal care products, contributing to their sensory appeal and safety.
Used in Dye Industry:
4-(DIMETHYLAMINO)BENZHYDROL is used as an intermediate in the production of dyes, where its chemical properties are leveraged to create a range of colorants for textiles, plastics, and other materials. Its versatility in chemical reactions enables the creation of dyes with specific color characteristics and improved performance properties.
Used in Organic Compounds Production:
4-(DIMETHYLAMINO)BENZHYDROL is also employed in the synthesis of other organic compounds, serving as a versatile building block in organic chemistry. Its reactivity and structural features make it a valuable component in the development of specialty chemicals and materials with diverse applications across various industries.

InChI:InChI=1/C15H17NO/c1-16(2)14-10-8-13(9-11-14)15(17)12-6-4-3-5-7-12/h3-11,15,17H,1-2H3

Upstream product

• 100-52-7 benzaldehyde 
• 121-69-7 N,N-dimethyl-aniline 
• 934-56-5 trimethyl(phenyl)stannane 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 100-58-3 phenylmagnesium bromide 
• 603-76-9 1-methylindole 
• 591-51-5 phenyllithium 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 1623-99-0 phenyl sodium 
• 98-80-6 phenylboronic acid 
• 60-29-7 diethyl ether 

Downstream Products

• 88103-87-1 N,N-dimethyl-4-[α-(toluene-4-sulfonyl)-benzyl]-aniline 
• 861330-53-2 (4-dimethylamino-benzhydryl)-malonic acid 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 108618-62-8 4-(amino(phenyl)methyl)-N,N-dimethylaniline 
• 129-73-7 bis(4-dimethylaminophenyl)phenylmethane 
• 21571-75-5 N,N-dimethyl-4-(α-p-tolylsulfanyl-benzyl)-aniline 
• 857595-67-6 (4-diethylamino-phenyl)-(4-dimethylamino-phenyl)-phenyl-methane 
• 2491-74-9 N,N-dimethyl-4-(4-nitrophenylazo)aniline 
• 100-52-7 benzaldehyde 
• 1629958-87-7 C₁₈H₂₁NO 
• 1629958-86-6 C₁₈H₂₁NO 
• 530-44-9 4-(Dimethylamino)benzophenone 
• 159334-91-5 (4-dimethylaminophenyl)(2-pyrrolyl)phenylmethane 
• 159334-92-6 2,5-bis[(4-dimethylaminophenyl)phenylmethyl]pyrrole 

Relevant academic research and scientific papers

Nickel-Mediated Enantiospecific Silylation via Benzylic C-OMe Bond Cleavage

Benzylic stereocenters are found in bioactive and drug molecules, as enantiopure benzylic alcohols have been used to build such a stereogenic center, but are limited to the construction of a C-C bond. Silylation of alkyl alcohols has the potential to build bioactive molecules and building blocks; however, the development of such a process is challenging and unknown. Herein, we describe an unprecedented AgF-assisted nickel catalysis in the enantiospecific silylation of benzylic ethers.

Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives

Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials. The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method. Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol.

Diarylmethanols synthesis by nickel(II)-catalyzed addition of arylboronic acids to aryl aldehydes

A practical procedure for the addition of arylboronic acids to aromatic aldehydes has been developed in the presence of NiCl2(PPh3)2/1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (IPr·HCl) system with good yield. Generally, electron-rich and-neutral aryl aldehydes showed excellent reactivity and provided desired products in high yields. This procedure will provide new way to the synthesis of diarylmethanols.

A Direct Br?nsted Acid-Catalyzed Azidation of Benzhydrols and Carbohydrates

Benzhydryl alcohols were converted into their corresponding diarylazidomethane analogues using azidotrimethylsilane (TMSN3) in the presence of a catalytic amount of a Br?nsted acid HBF4·OEt2. The azidation reactions proceeded in high yields and demonstrated excellent functional group tolerance to electron-donating and electron-withdrawing substituents. In addition, a range of unprotected functional groups including amine, amide, aldehyde and alcohol were well-tolerated. Furthermore, this methodology was successfully applied to carbohydrates for the preparation of the corresponding azide derivatives.

Di(hetero)arylmethanol compound preparation method

The invention belongs to the field of organic synthesis, and particularly relates to a di(hetero)arylmethanol compound preparation method, wherein the di(hetero)arylmethanol compound is prepared in ahigh-yield manner by using commercially available (hetero)aryl aldehyde and commercially available (hetero)arylboronic acid as raw materials and using a cheap and stable divalent nickel source as a catalyst. According to the present invention, the method improves the shortcomings of harsh reaction conditions, more side reactions, difficult post-treatment and the like caused by the general use of metal reagents, avoids the defects of high cost of catalytic reactions of noble metals such as palladium and the like and difficulty in mass production, has characteristics of mild conditions, convenient operation, low cost, high efficiency and environmental friendliness, and is suitable for practical scale production.

Direct allylation of benzyl alcohols, diarylmethanols, and triarylmethanols mediated by XtalFluor-E

We report the direct allylation of benzyl alcohols, diarylmethanols and triarylmethanols mediated by XtalFluor-E using allyltrimethylsilane. The resulting allylated products are obtained in moderate to high yield.

Coupling of aromatic aldehydes with aryl halides in the presence of nickel catalysts with diazabutadiene ligands

Nickel catalysts with diazabutadiene ligands promote cross-coupling of benzaldehydes with aryl halides in the presence of zinc as reducing agent, which leads to the corresponding benzhydrols and benzophenones. The benzophenone percentage considerably increases when lithium chloride additive is used.

Catalyst free, three-component approach for unsymmetrical triarylmethanes (TRAMs)

An efficient catalyst free, three-component, cascade approach has been designed and developed for the rapid assembly of unsymmetrical triarylmethane framework. The strategy employed aromatic aldehydes, Grignard reagents, and neutral aromatics as reaction

Synergistic stereoselective organocatalysis with indium(III) salts

The compatibility of indium(III) Lewis acids with water and amines allows their employment in synergistic and cooperative catalysis. Stereoselective organocatalytic SN1-type reactions, in which carbenium ions are generated, are promoted by the presence of indium salts. The peculiar properties of indium salts can be exploited in organocatalysis for the design of water-compatible, benign, green processes. The development of such indium(III)-promoted organocatalytic procedures is the focus of our recent research, a summary of which is presented in this article. Georg Thieme Verlag Stuttgart.New York.

Mesityllithium and p-(dimethylamino)phenyllithium for the selective alternate trilithiation of the hexaphenylbenzene framework

We report mesityllithium and p-(dimethylamino)phenyllithium as new valuable lithiating reagents, which realize Br/Li exchange reaction of bromoarenes at relatively high temperature in THF. With these reagents, we established the general and practical protocols for the selective alternate trilithiation of the hexaphenylbenzene framework. This journal is the Partner Organisations 2014.