1562526-67-3

Basic information

• Product Name: 2-(2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)-4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione
• CAS NO: 1562526-67-3
• Molecular Weight: 456.299
• Mol File: 1562526-67-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)-4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)-4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione(1562526-67-3)
• EPA Substance Registry System: 2-(2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)-4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione(1562526-67-3)

Safety Data

• Hazardous Substances Data: 1562526-67-3(Hazardous Substances Data)

Upstream product

• 1206515-76-5 4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione 
• 90929-77-4 1-(2-hydroxyethyl)-7-azaindole 

Downstream Products

• 1562526-70-8 2-(2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)-6-(benzyloxy)-4-(benzyloxymethyl)-1,2,4-triazine-3,5(2H,4H)-dione 

Relevant articles and documents

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel d -Amino Acid Oxidase Inhibitors

A series of 2-substituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of d-amino acid oxidase (DAAO). Many compounds in this series were found to be potent DAAO inhibitors, with IC50 values in the double-digit nanomolar range. The 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione pharmacophore appears metabolically resistant to O-glucuronidation unlike other structurally related DAAO inhibitors. Among them, 6-hydroxy-2-(naphthalen-1-ylmethyl)-1,2,4-triazine-3,5(2H,4H)-dione 11h was found to be selective over a number of targets and orally available in mice. Furthermore, oral coadministration of d-serine with 11h enhanced the plasma levels of d-serine in mice compared to the oral administration of d-serine alone, demonstrating its ability to serve as a pharmacoenhancer of d-serine.