1562661-12-4Relevant articles and documents
Protecting group free synthesis of carboxyl-substituted dihydropyrimidines through Biginelli reaction
Ostapchuk, Eugeniy N.,Plaskon, Andrey S.,Grygorenko, Oleksandr O.,Tolmachev, Andrey A.,Ryabukhin, Sergey V.
, p. 1299 - 1303 (2014/01/06)
Chlorotrimethylsilane-promoted Biginelli-type reaction of benzaldehyde, acetoacetic acid derivatives, and various carboxyl-containing ureas was explored. It was found that the steric load of the urea substituents influenced strongly the reaction outcome; in particular, the method was efficient only in the case of unbranched mono-substituted ureas bearing either aliphatic or aromatic groups. The method allows performing a one-pot, protecting group free synthesis of dihydropyrimidines possessing carboxylic functionality.
