156271-17-9Relevant academic research and scientific papers
Reductiv Amination of 1,4- and 1,5-Dicarbonyl Compounds with (S)-Valine Methyl Ester. Synthesis of (S)-2-Phenylpyrrolidine and (S)-2-Phenylpiperidine
Manescalchi, Francesco,Nardi, Anna R.,Savoia, Diego
, p. 2775 - 2778 (1994)
The reductive amination of 4-phenyl-4-oxobutanal and 5-phenyl-5-oxopentanal with (S)-valine methyl ester and sodium cyanoborohydride afforded the N-substituted (S)-2-phenylpyrrolidine (88percent d. e.) and (S)-2-phenylpiperidine (96percent d.e.), from whi
