Reductiv Amination of 1,4- and 1,5-Dicarbonyl Compounds with (S)-Valine Methyl Ester. Synthesis of (S)-2-Phenylpyrrolidine and (S)-2-Phenylpiperidine

Article abstract of DOI:10.1016/S0040-4039(00)77030-4

The reductive amination of 4-phenyl-4-oxobutanal and 5-phenyl-5-oxopentanal with (S)-valine methyl ester and sodium cyanoborohydride afforded the N-substituted (S)-2-phenylpyrrolidine (88percent d. e.) and (S)-2-phenylpiperidine (96percent d.e.), from whi