Reductiv Amination of 1,4- and 1,5-Dicarbonyl Compounds with (S)-Valine Methyl Ester. Synthesis of (S)-2-Phenylpyrrolidine and (S)-2-Phenylpiperidine

DOI: 10.1016/S0040-4039(00)77030-4

Source and publish data:

Tetrahedron Letters p. 2775 - 2778 (1994)

Update date:2022-08-05

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Authors:

Manescalchi, Francesco

Nardi, Anna R.

Savoia, Diego

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Article abstract of DOI:10.1016/S0040-4039(00)77030-4

The reductive amination of 4-phenyl-4-oxobutanal and 5-phenyl-5-oxopentanal with (S)-valine methyl ester and sodium cyanoborohydride afforded the N-substituted (S)-2-phenylpyrrolidine (88percent d. e.) and (S)-2-phenylpiperidine (96percent d.e.), from whi

Full text of DOI:10.1016/S0040-4039(00)77030-4

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