156294-33-6

Basic information

• Product Name: 7-deoxy-7β,8β-methanobaccatin III
• Synonyms: 7-deoxy-7β,8β-methanobaccatin III
• CAS NO: 156294-33-6
• Molecular Weight: 568.621
• Mol File: 156294-33-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 694.5±55.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 7-deoxy-7β,8β-methanobaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 7-deoxy-7β,8β-methanobaccatin III(156294-33-6)
• EPA Substance Registry System: 7-deoxy-7β,8β-methanobaccatin III(156294-33-6)

Safety Data

• Hazardous Substances Data: 156294-33-6(Hazardous Substances Data)

Upstream product

• 158811-19-9 10-acetyl-7-trifluoromethanesulfonate baccatin III 
• 31077-81-3 7-epi-baccatine III 
• 71629-92-0 10-deacetyl-7-epi-baccatin III 
• 27548-93-2 baccatin III 
• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 156294-35-8 (2α,3α,4α,5β,7α,10β,13α)-4,10-bis(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-9-oxo-5,20-epoxy-7,19-cyclotax-11-en-2-yl benzoate 
• 156294-36-9 7-deoxy-7β, 8β-methylene-10-O-acetyldocetaxel 

Relevant articles and documents

A semi-synthetic taxane derivative and its preparation method and application

The invention discloses a semi-synthetic taxane derivative. An anti-tumor effect test shows that the semi-synthetic taxane derivative has relatively good anti-tumor activity on a human lung adenocarcinoma cell line A549, a human breast cancer cell line MCF-7, a human glioblastoma cell line U251, a human pancreatic cancer cell line PANC-1, a human colon cancer cell line HCT116 and a human non-small lung cancer cell line H460. The semi-synthetic taxane derivative can be used for preparing anti-tumor drugs.

PROCESS FOR PREPARING TAXOIDS FROM BACCATIN DERIVATIVES USING LEWIS ACID CATALYST

The present invention relates to a process of preparing a taxoid (X) by reacting a protected baccatin derivative (B) with a β-lactam (C) in the presence of one or more Lewis acids and a base agent. The present invention also relates to a process of preparing the protected baccatin derivative (B) from a baccatin derivative (A) comprising a protection reaction catalyzed by one or more Lewis acids with an optional base agent.