156294-36-9

Basic information

• Product Name: Larotaxel
• Synonyms: Larotaxel;PNU 100940
• CAS NO: 156294-36-9
• Molecular Formula: C₄₅H₅₃NO₁₄
• Molecular Weight: 831.90062
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 156294-36-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 889.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.37
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 11.20±0.46(Predicted)
• CAS DataBase Reference: Larotaxel(CAS DataBase Reference)
• NIST Chemistry Reference: Larotaxel(156294-36-9)
• EPA Substance Registry System: Larotaxel(156294-36-9)

Safety Data

• Hazardous Substances Data: 156294-36-9(Hazardous Substances Data)

Usage

Uses

Larotaxel (RPR 109881A) is a taxane analog with a broad spectrum of activity and different toxicity profile and with the possible advantages of surpassing some mechanisms of resistance and penetrating into the CNS.

Upstream product

• 32981-86-5 10-deacetylbaccatin III 
• 27548-93-2 baccatin III 
• 158811-19-9 10-acetyl-7-trifluoromethanesulfonate baccatin III 
• 156294-33-6 7-deoxy-7β,8β-methanobaccatin III 
• 156294-35-8 (2α,3α,4α,5β,7α,10β,13α)-4,10-bis(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-9-oxo-5,20-epoxy-7,19-cyclotax-11-en-2-yl benzoate 
• 100-52-7 benzaldehyde 
• 101067-78-1 (+/-)-(3R,4S)-3-hydroxy-4-phenyl-N-(4-methoxyphenyl)azetidin-2-one 
• 131968-76-8 (+/-)-(3R,4S)-3-acetoxy-N-(4-methoxyphenyl)-4-phenylazetidin-2-one 
• 71629-92-0 10-deacetyl-7-epi-baccatin III 
• 31077-81-3 7-epi-baccatine III 

Downstream Products

• 1308398-58-4 larotaxel β-alanine glycolate 
• 1321582-53-9 larotaxel MMT-aminoethyldithioethyl carbonate 
• 1308398-56-2 larotaxel Cbz-β-alanine glycolate 
• 1308398-61-9 larotaxel aminoethoxyethoxy acetate methansulfonate 
• 1308398-59-5 larotaxel Cbz-aminoethoxyethoxy acetate 
• 1308398-55-1 larotaxel glycinate methansulfonate 
• 1308398-64-2 larotaxel aminohexanoate methanosulfonate 
• 1308398-62-0 larotaxel Cbz-aminohexanoate 
• 1308398-53-9 larotaxel Cbz-glycinate 

Relevant articles and documents

A semi-synthetic taxane derivative and its preparation method and application

The invention discloses a semi-synthetic taxane derivative. An anti-tumor effect test shows that the semi-synthetic taxane derivative has relatively good anti-tumor activity on a human lung adenocarcinoma cell line A549, a human breast cancer cell line MCF-7, a human glioblastoma cell line U251, a human pancreatic cancer cell line PANC-1, a human colon cancer cell line HCT116 and a human non-small lung cancer cell line H460. The semi-synthetic taxane derivative can be used for preparing anti-tumor drugs.

PROCESS FOR PREPARING TAXOIDS FROM BACCATIN DERIVATIVES USING LEWIS ACID CATALYST

The present invention relates to a process of preparing a taxoid (X) by reacting a protected baccatin derivative (B) with a β-lactam (C) in the presence of one or more Lewis acids and a base agent. The present invention also relates to a process of preparing the protected baccatin derivative (B) from a baccatin derivative (A) comprising a protection reaction catalyzed by one or more Lewis acids with an optional base agent.