1563182-47-7

Upstream product

• 619254-64-7 2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 
• 619254-63-6 methyl 2-(3,4-dichlorophenyl)-2-methylpent-4-enoate 
• 1563182-48-8 C₈H₁₁N*C₁₂H₁₂Cl₂O₂ 
• 173457-29-9 2-(3,4-dichloro-phenyl)-pent-4-enoic acid methyl ester 
• 79333-48-5 2-(S)-(3,4-dichloro-phenyl)-4-pentenoic acid 
• 5807-30-7 3,4-dichlorophenyl acetic acid 

Downstream Products

• 1563182-54-6 (R)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 2-trimethylsilanylethyl ester 
• 1563183-30-1 tert-butyl 2-((R)-2-((R)-2-(3,4-dichlorophenyl)-N,2-dimethylpent-4-enamido)-3-phenylpropanamido)ethylcarbamate 
• 1563183-36-7 tert-butyl 3-((R)-2-((R)-2-(3,4-dichlorophenyl)-N,2-dimethylpent-4-enamido)-3-phenylpropanamido)propylcarbamate 
• 1563183-38-9 tert-butyl 3-((R)-2-((R)-2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-N,2-dimethylbutanamido)-3-phenylpropanamido)propylcarbamate 
• 1563183-32-3 tert-butyl 2-((R)-2-((R)-2-(3,4-dichlorophenyl)-N,2-dimethyl-4-oxobutanamido)-3-phenylpropanamido)ethylcarbamate 
• 1563181-88-3 C₃₇H₄₄Cl₂FN₅O₄ 
• 1563181-92-9 (R)-2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-N-((R)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl)-2-methylbutanamide 
• 1563183-06-1 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-2-methyl butanamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 
• 1563183-02-7 (R)-2-(trimethylsilyl)ethyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-2-methylbutanoate 
• 1563183-00-5 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-2-methyl-4-(1-methyl-2-oxospiro[indoline-3,4'-piperidine]-1'-yl)butanamido)-3-phenylpropanamido) ethyl carbamic acid benzyl ester 
• 1563182-56-8 (R)-2-(trimethylsilyl)ethyl 2-(3,4-dichlorophenyl)-2-methyl-4-oxobutanoate 
• 1563182-90-0 (R)-3-(3,4-dichlorophenyl)-5-hydroxy-3-methyldihydrofuran-2(3H)-one 
• 1563182-97-7 (R)-2-(3,4-dichlorophenyl)-2-methyl-4-(1-methyl-2-oxospiro[indoline-3,4'-piperidine]-1'-yl)butanoic acid 
• 1563182-95-5 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-2-methyl-4-(4-(N-propylmethylsulfonamido)piperidin-1-yl)butanamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 

Relevant academic research and scientific papers

Nickel/Enamine Cooperative Catalysis Enables Highly Enantioselective Allylic Alkylation of α-Branched Aldehydes

All-carbon quaternary stereocenters constitute a significant portion of natural products and bioactive compounds. Here we disclose a nickel and chiral amine cooperative catalysis to enable a highly enantioselective allylic alkylation reaction between α-branched aldehydes and a wide scope of allyl esters, allowing the all-carbon quaternary stereocenter to be accessed with excellent enantioselectivity (up to 98% ee) and structural diversity. The general synthetic applicability has been showcased by the enantioselective synthesis of key chiral building blocks to access (+)-eptazocine, (?)-aphanorphine, and other two bioactive compounds.

Design, synthesis, and optimization of balanced dual NK1/NK 3 receptor antagonists

In connection with a program directed at potent and balanced dual NK 1/NK3 receptor ligands, a focused exploration of an original class of peptidomimetic derivatives was performed. The rational design and molecular hybridization of a novel phenylalanine core series was achieved to maximize the in vitro affinity and antagonism at both human NK1 and NK3 receptors. This study led to the identification of a new potent dual NK1/NK3 antagonist with pKi values of 8.6 and 8.1, respectively.