156335-17-0Relevant academic research and scientific papers
Competing O - H insertion and β-elimination in rhodium carbenoid reactions; synthesis of 2-alkoxy-3-arylpropanoates
Cox, Geoffrey G.,Haigh, David,Hindley, Richard M.,Miller, David J.,Moody, Christopher J.
, p. 3139 - 3142 (1994)
Rhodium(II) carboxylate catalysed decomposition of diazo esters 3 and 4 in the presence of alcohols or water results in formation of 2-alkoxy- or 2-hydroxy-3-arylpropanoates respectively by O - H insertion in competition with cinnamates by elimination; the ratio of insertion to elimination is dramatically affected by the carboxylate ligand on rhodium. Use of methanol-d as the alcohol confirms that the alkene does not arise by elimination from the initial alkoxyester product.
Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ
Liu, Kevin G,Smith, Jennifer S,Ayscue, Andrea H,Henke, Brad R,Lambert, Millard H,Leesnitzer, Lisa M,Plunket, Kelli D,Willson, Timothy M,Sternbach, Daniel D
, p. 2385 - 2388 (2007/10/03)
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPARα and PP
